规范吸入糖皮质激素在 COPD 稳定期中的疗效观察  

Curative effect of specification of inhaled corticosteroids in stable phase of COPD

作　　者：张瑞青[1] 祖军[1] 陈建军[1] 陈建平[1] 王海丽[1] 刘颖[1] 

机构地区：[1]江苏省泗洪县分金亭医院呼吸科,江苏泗洪223900

出　　处：《世界最新医学信息文摘》2014年第27期97-98,共2页World Latest Medicine Information Electronic Version

摘　　要：目的：探讨规范吸入糖皮质激素在 COPD 稳定期中的疗效。方法将我科2011至2013年收治的90例 COPD 患者分为两组，除常规氧疗、祛痰、戒烟、呼吸肌锻炼等治疗外，治疗组出院后规范吸入糖皮质激素（沙美特罗替卡松粉吸入剂50μg/250μg，商品名：舒利迭），对照组按需吸入支气管扩张剂（沙丁胺醇气雾剂及异丙托溴胺气雾剂），观察他们在出院后三月内急性发作需要住院治疗的次数或恶性事件（指发生呼吸衰竭需要无创通气或气管插管呼吸机使用、死亡等）的次数。结果通过观察，治疗组在恶性事件发生率及再次住院率等方面明显低于对照组。结论规范吸入糖皮质激素（沙美特罗替卡松粉）的患者，出院后三月内急性发作需要住院治疗的次数或恶性事件的次数明显低于单用支气管扩张剂的患者，长期使用糖皮质激素吸入剂可明显减少急性发作的次数，降低住院率，减少费用。Objective To investigate the effect of specification of inhaled corticosteroids on COPD in stable period. Methods 90 cases of coPd patients in our department from 2011 to 2013 were divided into two groups, in addition to conventional oxygen therapy, given expectorant, quitting smoking and respiratory muscle exercise therapy, the patients in treatment group after discharge received standard inhaled corticosteroid （fluticasone propionate powder for inhalation of Shah Mette Lo, in a dose of 50ug/250ug, trade name： Shu Lidie）, while the patients in control group received inhaled bronchodilator on-demand agent （Salbutamol Aerosol and ipratropium bromide aerosol）. The hospitalization times caused by acute attack and malignant events times （refers to respiratory failure requiring non-invasive ventilation or tracheal intubation ventilator use, and the number of death） were observed for 3 months after discharge. Results The occurrence of malignant event and hospitalization times in the treatment group were significantly lower than that in control group. Conclusion the number of acute attack induced hospitalization times or malignant events after discharge for 3 months in patients who inhaled corticosteroids （Shah Mette Lo powder） with specification, was significantly lower than that of patients received the single use of bronchodilators. The number of acute attack, hospitalization times and costs can be significantly reduced after long-term use of inhaled corticosteroids.

关 键 词：吸入 糖皮质激素 COPD 

分 类 号：R[医药卫生]