食管癌调强放疗肿瘤退缩规律及其临床价值  

Intensity modulated radiation therapy （imrt） esophageal tumor regression law and its clinical value

作　　者：杨森[1] 王伟[1] 杨宛莹[1] 李芩[1] 刑超[1] 张开国[1] 满其荣[1] 张旭升[1] 袁倩倩[1] 胡苗苗[1] 张开贤[1] 

机构地区：[1]山东省滕州市中心人民医院,山东滕州277500

出　　处：《世界最新医学信息文摘》2014年第27期149-150,共2页World Latest Medicine Information Electronic Version

摘　　要：目的观察和探讨食管癌采用调强放疗肿瘤退缩的规律及临床应用价值。方法分析我院收治的38例食管癌患者，采用调强放疗进行治疗，收集在治疗过程中的所有肿瘤影像学资料，比较外照射前、照射至中位剂量达32Gy时、放疗结束时和放疗后6个月内患者实体肿瘤体积（gross tumor volume，GTV）变化情况，以及食管癌患者在治疗前半程、治疗后半程和治疗全程体积退缩率（volumereductionrate，VRR）。结果患者在接受外照射前GTv范围为（5．49-110．39）ml，平均值为（32．78±5．33）ml，在照射至中位剂量32Gy时GTv范围为（4．89-80．15）ml，平均值为（23．56±3．40）ml，在治疗结束后GTv范围为（4．47-78．88）ml，平均值为（21．57±3．06）ml，治疗后6个月GTV范围为（5．06-32．96）ml，平均值为r15．8±2．28）ml患者放疗前半程VRR范围为．0．0404）．622，平均值为r0．193±0．032），放疗后半程VRR范围为-0．414-0．311，平均值为（0．050±0．030），放疗全程VRR范围为．0．267—0．695，平均值为（0．225±0．046）；在接受放疗前半程患者VRR明显高于后半程，差异具有统计学意义（P〈0．05）。结论食管癌患者在接受放疗中瘤体体积不断退缩，退缩主要是在放疗前半程，医务工作者应根据影像学检查结果及时调整放疗靶区和放射剂量，在保证靶区高计量放射的同时，减少对周围组织的损伤。Objective： to observe and investigate esophageal intensity modulated radiation therapy （imrt） using rule and clinical value of tumor regression. Method analysis of our hospital of 38 patients with esophageal cancer, using intensity- modulated radiotherapy treatment, in the treatment of all tumor imaging in the process of information collection, comparison of external exposure, expOsure to the median dose of 32 Gy before when, at the end of radiotherapy and radiotherapy in patients with solid tumors within six months after the volume （gross tumor volume, GTV）, and esophageal cancer patients in the treatment of first half, second half and the entire treatment volume shrinking rate （volume reduction rate, VRR）. Results patients before undergoing external exposure GTV range for ml （5.49-110.39）, average （32.78-5.33） for ml, when exposure to the median dose of 32 Gy GTV scope for ml （4.89-80.15）, average ofml （23.56 ＋ 3.40）, at the end of the treatment of GTV range for ml （4.47-78.88）, average （21.57-3.06） for ml, 6 months after treatment of GTV range for ml （5.06-32.96）, average of ml （15.8 ＋ 2.28） patients before radiotherapy half VRR range to 0.040-0.622, average （0.193 ＋ 0.032）, second half radiotherapy VRR range to 0.414-0.311, average （0.050 ＋ 0.030）, radiotherapy VRR range to 0.267-0.267 - all the way, the average （0.225 ＋ 0.046）; In the first half radiotherapy patients VRR significantly higher than the second half, statistically significant difference （P 〈 0.05）. Conclusion esophageal cancer patients undergoing radiotherapy in tumors had constantly shrinking volume, retreat is mainly in the first half, radiation medical workers should be according to the Results of imaging examination in a timely manner to adjust target and the radiation dose radiotherapy, the guarantee at the same time, the high dose radiation of the target to reduce damage to the surrounding, tissues.

关 键 词：食管癌 调强放疗大体肿瘤体积 肿瘤退缩率 

分 类 号：R73[医药卫生—肿瘤]