室温下铜催化制备含羰基或酯基的喹唑啉-4(3H)-亚基类衍生物  

Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature

作　　者：谢瑞龙[1] 杨新玲[1] 秦耀果 谭晓庆[1] 凌云[1] 

机构地区：[1]中国农业大学理学院应用化学系农业部农药化学及应用重点开放实验室,北京100193

出　　处：《有机化学》2014年第10期2076-2082,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21272266);国家"十二五"科技支撑计划课题(No.2011BAE06B05-5)资助项目~~

摘　　要：在室温的条件下,建立了一种简单实用的铜催化制备含酮羰基或酯基的喹唑啉-4(3H)-亚基类衍生物的新方法.实验证明以2-溴苯甲酰乙酸甲酯类似物及脒盐酸盐为原料,碘化亚铜为催化剂,磷酸钾为碱,无添加配体的情况下,可成功制备一系列喹唑啉类衍生物.其结构均经1H NMR、13C NMR及HRMS确证.At room temperature, a new simple and efficient copper-catalyzed method for the synthesis of quinazolin- 4（3H）-ylidene derivatives containing carbonyl and ester group was developed. The targets were prepared using methyl 3-（2-bromophenyl）-3-oxopropanoate analogues and amidine hydrochlorides as the initial materials, cuprous iodide as catalyst, and potassium phosphate as base at the ligand-ffee condition. Their structures were confirmed by ^1H NMR, ^13C NMR and HRMS.

关 键 词：铜 室温 催化 喹唑啉 

分 类 号：O626[理学—有机化学]