氨基脲催化下碳亲核试剂和氮亲核试剂对查尔酮的Michael加成反应  

Michael Addition of Carbon and Nitrogen Nucleophiles with Chalcone Catalyzed by Semicarbazide

作　　者：程贺龙[1] 高玉华[1] 聂士鹏 陆鸿飞[1] 

机构地区：[1]江苏科技大学生物与化学工程学院,镇江212003

出　　处：《有机化学》2014年第10期2083-2089,共7页Chinese Journal of Organic Chemistry

摘　　要：以查尔酮、丙二酸酯、丙二腈、苯胺为原料,水为溶剂,苯丙氨酸脲化合物为催化剂,三氟甲磺酸为助剂60℃下反应,高产率得到Michael加成产物.该方法具有催化剂合成简单、环境友好等优点.An efficient Michael addition of chalcone and malonate, malononitrile, aniline catalyzed by phenylalanine-urea in water has been disclosed at 60 ℃ with trifluoromethanesulfonate, affording the corresponding adducts in good yields, while the catalyst was easy to handle up and the solvent was environmentally friendly.

关 键 词：查尔酮 丙二酸酯 苯丙氨酸脲化合物 MICHAEL加成 

分 类 号：O621.251[理学—有机化学]