阿归养血颗粒油状物β-环糊精包合工艺研究  

Extracting Process of Aguiyangxue particles by the Continuous Counter-current Equipment

作　　者：程丽娟[1] 乐治平[1] 易航 何纯斌 杨明 文万江 

机构地区：[1]南昌大学,江西南昌330000 [2]江西济民可信药业有限公司,江西宜春336000

出　　处：《中国医药指南》2014年第31期14-15,共2页Guide of China Medicine

摘　　要：目的应用多指标综合评分法结合正交设计,优选阿归养血颗粒油状物β-环糊精最佳包合工艺。方法以包合物油利用率、包合物含油率、包合物收得率为考察指标,经多指标综合评分法结合正交设计,考察油状物/β-环糊精(mL/g)、包合时间、包合温度、乙醇/油状物(%)等因素,最终确立阿归养血颗粒油状物β-环糊精最佳包合工艺。结果最佳包合工艺:即油状物/β-环糊精为1:10,包合温度为40℃,乙醇/油状物为20%,包合1 h。结论采用多指标评分法结合正交设计优选得到阿归养血颗粒油状物最佳包合工艺,为阿归养血颗粒制备及相关研究提供了一定理论依据。Objective To optimize the β-cyclodextrin inclusion process of Aguiyangxue particles under the application of multi-index comprehensive evaluation method combined with orthogonal experiment design. Methods Using the indexes of the rate of utilization of inclusion oil and the content of inclusion oil and the amount of the inclusion to investigate the oil-like substances/β-cyclodextrin（mL/g）, inclusion time, inclusion temperature and ethanol/oil-like substances（%）,and then to establish the optimicalβ-cyclodextrin inclusion process. Results The optimumβ-cyclodextrin inclusion process：the oil-like substances/β-cyclodextrin（mL/g） is 1∶10, inclusion temperature is 40℃, and inclusion time is 1 h, ethanol/oil-like substances （%） is 20%. Conclusion Theβ-cyclodextrin inclusion process of Aguiyangxue particles after the multi-index scores conbined with orthogonal experiment design provides a scientific basis for the clinical use.

关 键 词：阿归养血颗粒 油状物 Β-环糊精 包合 

分 类 号：R283.6[医药卫生—中药学]