MMP-2蛋白及E-cad蛋白在胰腺癌组织中的表达及临床意义探索和研究  

Expression and Clinical Significance of MMP-2 and E-cad Protein in Pancreatic Tissue Exploration and Research

作　　者：田峰 方瑞忠 费志勇 

机构地区：[1]山东省沂水中心医院消化内科,山东临沂276499

出　　处：《中国医药指南》2014年第31期47-47,49,共2页Guide of China Medicine

摘　　要：目的探讨MMP-2蛋白及E-cad蛋白在胰腺癌组织中的表达及临床意义。方法收集2011年12月至2013年1月本院确诊的胰腺癌组织标本30例设为观察组,收集同期正常胰腺组织10例设为对照组,采取免疫组织化学法对两组胰腺组织中MMP-2、E-cad的表达情况进行观察。结果观察组MMP-2蛋白阳性率为93.33%,E-cad蛋白阳性率为96.67%;对照组MMP-2蛋白阳性率为60%,E-cad蛋白阳性率为20%,观察组的MMP-2蛋白阳性率及E-cad蛋白阳性率均显著高于对照组,P<0.05,有统计学意义;MMP-2蛋白、E-cad蛋白阳性表达和胰腺癌的分化程度有一定关联;MMP-2蛋白、E-cad蛋白阳性表达和胰腺癌是否存在淋巴结转移有一定关联。结论 MMP-2蛋白在胰腺癌组织中呈高表达,E-cad蛋白在胰腺癌组织中呈低表达,且二者表达情况和胰腺癌组织的分化程度以及是否存在淋巴结转移均有密切关联。Objective To investigate the expression and clinical significance of MMP-2 and E-cad protein in pancreatic tissue. Methods December 2011 January 2013 hospital diagnosed 30 cases of pancreatic tissue observation group to collect the same period 10 cases of normal pancreatic tissue as control group, taking two groups of immunohistochemistry pancreatic tissue MMP-2, E-cad expression was observed. Results Observation group MMP-2 protein positive rate of 93.33%, E-cad protein positive rate was 96.67%;controls MMP-2 protein positive rate 60%, E-cad protein positive rate was 20%in the observation group MMP-the positive rate of E-cad 2 protein and protein-positive rate was significantly higher, P＆lt;0.05, statistically significant;MMP-2 protein, E-cad expression and differentiation of certain proteins associated with pancreatic cancer;MMP-2 protein , E-cad protein expression and pancreatic lymph nodes if there is a certain association. Conclusion MMP-2 protein was highly expressed, E-cad protein expression was lower in pancreatic cancer in pancreatic cancer, and both the expression and the degree of differentiation of pancreatic cancer, and whether the presence of lymph node metastases are closely related.

关 键 词：MMP-2蛋白 E-CAD蛋白 胰腺癌组织 表达 

分 类 号：R735.9[医药卫生—肿瘤]