三维适形放射治疗联合同步化疗治疗食管癌的临床观察  

Clinical observation of three dimensional conformal radiotherapy combined with chemotherapy for esophageal cancer

作　　者：顾红芳[1] 王向前[1] 许春明[1] 黄灿红[1] 朱琪伟[1] 

机构地区：[1]江苏省南通市肿瘤医院放射治疗科,南通226361

出　　处：《中国肿瘤临床与康复》2014年第10期1221-1223,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的分析三维适形放射治疗联合同步化疗治疗食管癌的临床效果。方法选取2010年1月至2012年1月间收治的62例食管癌患者,随机分为观察组和对照组,观察组32例患者采用三维适形放射治疗联合同步化疗治疗方案,对照组30例患者采用单独放射治疗方案,观察两组患者近期疗效、生存率和不良反应。结果观察组近期疗效为81.2%,高于对照组的63.3%,差异有统计学意义(P<0.05),观察组、对照组的8个月生存率分别为62.5%和56.7%,差异无统计学意义(P>0.05),16个月生存率分别为46.9%和30.0%,差异有统计学意义(P<0.05)。不良反应主要为放射性食管炎、恶心呕吐、白细胞减少等,且观察组高于对照组。结论三维适形放射治疗联合同步化疗治疗食管癌可提高近期疗效和生存率,虽然不良反应增加,但患者可以耐受。Objective To analyzes the clinical effect of three dimensional conformal radiotherapy（ 3D-CRT） combined with concurrent chemotherapy for esophageal cancer.Methods From January2010 to January 2012,62 cases of esophageal cancer patients were choosed randomly,and divided into two groups,the observation group（ n = 32） were treated with three dimensional conformal radiotherapy（ 3D-CRT） with concurrent chemoradiotherapy treatment; the control group（ n = 30） were treated with radiotherapy alone scheme.The recent curative effects,the survival rate and adverse reaction of two groups patients were observed.Results In the observation group,curative effect was 81.2%,higher than that of the control group 63.3%,two groups had significant difference（ P〈 0.05）,The observation group,the control group survival rates were 62.5% and 56.7% in 8 mo later,two groups is not statistically significant（ P〉 0.05）,16 mo later the survival rates were 46.9% and 30.0%,there were significant differences between the two groups（ P〈 0.05）; adverse reaction toradiation esophagitis,nausea vomiting,decreased white blood cells,and the observation group was higher than control group.Conclusion 3D-CRT combined with concurrent chemotherapy for esophageal cancer to improve the efficacy and survival rate of adverse reactions,althoughincreased,but patients can be tolerated.

关 键 词：三维适形放射治疗 同步放化疗 食管肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]