上皮性卵巢癌中Bikunin的表达及意义  

The expression and clinical significance of Bikunin in epithelial ovarian cancer

作　　者：王晓蓉[1] 蔡喆[1] 

机构地区：[1]珠海市妇幼保健院,广东519000

出　　处：《医学动物防制》2014年第10期1139-1142,1145,共5页Journal of Medical Pest Control

基　　金：珠海市科技计划项目(2011B040102008)

摘　　要：目的从蛋白水平探讨Bikunin,又称尿胰蛋白酶抑制剂(urinary trypsin inhibitor,UTI)在上皮性卵巢癌浸润、转移中的作用,及其在组织中的分布情况、与预后的关系。方法应用免疫组化法检测80份上皮性卵巢癌、20份良性卵巢肿瘤标本中Bikunin蛋白表达,并结合临床病理因素、预后进行分析。结果上皮性卵巢癌、良性卵巢肿瘤标本中Bikunin阳性率分别为55.0%、20.0%,两者差异有统计学意义(χ2=7.853,P=0.005)。上皮性卵巢癌中,Bikunin阳性与国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期早有显著性相关,差异有统计学意义(χ2=5.241,P=0.022),与上述其他临床病理因素差异无统计学意义(P>0.05)。多因素Cox回归模型显示,Bikunin表达是总生存的独立危险因素。结论上皮性卵巢癌中Bikunin表达上调,Bikunin有可能作为预测上皮性卵巢癌预后的参考指标。Objective This study investigated the role of Bikunin, also called urinary trypsin inhibitor （UTI）, in the infiltration and metastasis of epithelial ovarian cancer （EOC） , to clarify their localization and relationship with prognosis. Methods Immunohistochemistry was applied to examine the protein expression of Bikunin in 80 EOC tissues and 20 benign ovarian tumor tissues, the relationship between the expression of the two proteins and the clinic pathological characteristics, prognosis of the patients was analyzed. Results The positive rates of Bikunin in the 2 groups were 55.0% and 20.0% respectively, the difference was statistically significant （x^2 = 7. 853, P = 0. 005） . Higher expression of Bikunin was associated with early International Federa- tion of Gynecology and Obstetrics （FIGO） stage , the difference was statistically significant （x^2 = 5. 241, P = 0. 022）, but the difference was not statistically significant with the other parameters （P 〉 0. 05 ） . Multivariate analysis showed that Bikunin is an independent prognostic marker for overall survival. Conclusions Bikunin were up -regulated in EOC, Bikunin might be used as markers to predict the prognosis of patients with EOC.

关 键 词：尿胰蛋白酶抑制剂 卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]