埃索美拉唑镁肠溶片+阿莫西林胶囊+克拉霉素胶囊联合中药汤剂治疗消化性溃疡并出血的临床效果  

Clinical effects of esomeprazole, amoxicillin and clarithromycin combined with traditional Chinese medicine decoction in treatment of peptic ulcer bleeding

作　　者：潘秀霞[1] 孙琳[2] 

机构地区：[1]山东省安丘市人民医院药剂科,山东省安丘市262100 [2]山东省安丘市人民医院风湿免疫科,山东省安丘市262100

出　　处：《世界华人消化杂志》2014年第27期4181-4185,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨埃索美拉唑镁肠溶片+阿莫西林胶囊+克拉霉素胶囊联合中药汤剂治疗消化性溃疡出血(peptic ulcer bleeding,PUB)的临床效果.方法:按照实际用药情况将山东省安丘市人民医院收治的96例PUB患者分为中西医组61例和西医组35例,西医组患者给予埃索美拉唑镁肠溶片+阿莫西林胶囊+克拉霉素胶囊治疗,中西医组在此基础上加用中药汤剂辨证治疗,比较两组患者止血时间、治疗前后症状总积分变化情况以及疗程结束时幽门螺旋杆菌(Helicobacter pylori,H.pylori)根除情况以及临床疗效.结果:两组患者治疗后症状总积分均显著下降,与治疗前比较(10.62分±2.53分vs 33.50分±2.91分,17.30分1.98分vs 32.25分±2.48分),差异具有统计学意义(P<0.05);中西医组患者平均止血时间和治疗后症状总积分均显著低于西医组(3.02 d±1.48 d vs 4.48 d±1.72 d,10.62分±2.53分vs 17.30分±1.98分),差异具有统计学意义(P<0.05);中西医组患者疗程结束时H.pylori根除率显著高于西医组(93.44%vs 80.00%),差异具有统计学意义(P<0.05);中西医组患者治愈率和总有效率显著高于西医组(59.02%vs 34.29%,93.44%v s 82.86%),差异具有统计学意义(P<0.05).结论:中西医结合治疗PUB止血快,能够显著改善患者中医证候、提高H.pylori根除率和临床疗效,可作为治疗PUB的优选方案.AIM： To assess the clinical effects of esomepra- zole magnesium enteric-coated tablets, amoxi- cillin capsules and clarithromycin capsules combined with traditional Chinese medicine de- coction in the treatment of peptic ulcer bleeding （PUB）.METHODS： Ninety-six patients with PUB were divided into either a traditional Chinese medi- cine plus Western medicine group （n = 61） or a Western medicine alone group （n = 35） accord- ing to the medications. The Western medicinealone group was treated with esorneprazole magnesium enteric-coated tablets ＋ amoxicil- lin capsules ＋ clarithromycin capsules, and the combination group was additionally given tra- ditional Chinese medicine decoction on the basis of Western medicine treatment. The hemostasis time, total symptom score, Helicobacter pylori （H. pylori） eradication rate and clinical effects were compared for the two groups.RESULTS： The total symptom scores for the two groups were significantly lower after treat- ment than prior treatment （10.62 ± 2.53 vs 33.50 ± 2.91, 17.30 ± 1.98 vs 32.25 ± 2.48, P 〈 0.05）. The hemostasis time and total symptom score in the combination group were significantly lower than those in the Western medicine alone group （3.02 d ± 1.48 d vs 4.48 d ± 1.72 d, 10.62 ＋± 2.53 vs 17.30 ±1.98, P 〈 0.05）. The H. pylori eradication rate in the combination group was higher than that in the Western medicine alone group （93.44% vs 80.00%, P 〈 0.05）. The cure rate and total effective rate were significantly higher in the combination group than in the Western medicine alone group （59.02% vs 34.29%, 93.44% vs 82.86%, P 〈 0.05）.CONCLUSION： Esomeprazole, amoxicillin and clarithromycin combined with traditional Chi- nese medicine decoction can improve clinical symptoms, shorten hemostasis time, increase H. pylori eradication rate and improve clinical ef- fects in patients with PUB.

关 键 词：埃索美拉唑镁肠溶片 阿莫西林胶囊 克拉霉素胶囊 中药汤剂 消化性溃疡出血 

分 类 号：R573.1[医药卫生—消化系统]