80岁以上老年非小细胞肺癌切除术后并发症及预后分析  

Analysis of complications and outcomes after pulmonary resection in patients aged 80 years or over with non-small cell lung cancer

作　　者：李文兵[1] 高德伟[1] 卢文宁[1] 刘朝阳[1] 

机构地区：[1]解放军总医院外科ICU,北京100853

出　　处：《解放军医学杂志》2014年第10期823-825,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨80岁以上老年早期非小细胞肺癌根治性切除术的疗效及安全性。方法回顾性分析2003年1月-2012年12月解放军总医院连续收治的97例≥80岁,行肺部分切除术,术后病理证实为非小细胞肺癌的患者资料,对其术前、术中围术期状况进行评估,包括性别、年龄、吸烟史、肺功能、术前合并疾病以及手术方式、组织病理类型、病理分期等,分析上述因素与术后并发症发生及预后的关系。结果 97例患者中14例(14.4%)发生术后并发症,最常见原因为血管并发症(9例)和肺部并发症(5例)。所有病例中,36例行肺叶切除,31例行肺段切除,另有30例行楔形切除。组织病理类型为腺癌51例,鳞癌29例,大细胞癌9例,腺鳞癌6例,神经内分泌细胞癌2例。术后病理分期为ⅠA期55例,ⅠB期33例,ⅡA期7例,ⅢA期2例。2例因术后并发症死亡,其中1例死于术后肺炎、呼吸衰竭,另1例死于急性心肌梗死。所有病例术后1、3、5年生存率分别为91.7%、70.2%及52.8%。术后病理为Ⅰ期的患者,其术后1、3、5年生存率分别为93.9%、73.6%及54.1%。结论高龄并非早期非小细胞肺癌根治性切除术的禁忌证。Objective To explore the therapeutic effect and degree of safety in patients aged 80 years or over with nonsmall cell lung cancer undergoing radical resection. Methods A retrospective survey of 97 elder patients aged 80 years or over, in whom non-small cell lung cancer was pathologically confirmed after partial resection of the lung in Chinese PLA General Hospital from Jan. 2003 to Dec. 2012. The peri-operative features were evaluated, including gender, age, history of smoking, pulmonary function, surgical procedure, histopathologic type, pathologic stage, etc. The relation of the postoperative complications and mortality with the factors mentioned above was analyzed. Results Among all patients, the surgical procedure comprised 36 lobectomies, 31 segmentectomies, and 30 wedge resections. The histopathologic diagnosis showed there were adenocarcinoma in 51 patients, squamous cell carcinoma in 29, large cell carcinoma in 9, adenosquamous cell carcinoma in 6 and neuro-endocrine cell carcinomas in 2. The disease stage was determined as ⅠA in 55 cases, ⅠB in 33, ⅡA in 7, ⅢA in 2. The post-operative complications（POC） occurred in 14 of 97 patients（14.4%）, and the most common complication was cardiovascular complication（9 cases）, followed by pulmonary complication（5 cases）. Only two patients died to the complications, one of them was post-operative pneumonia and respiratory failure, and the other one was acute myocardial infarction. The survival rate of the 97 patients was 91.7%, 70.2% and 52.8% at 1, 3 and 5 years, respectively, and in the patients with stage I disease, the survival rate was 93.9%, 73.6% and 54.1%, respectively. Conclusion Advanced age is not a contraindication to radical pulmonary resection in patients over 80 years old suffering from early stage non-small cell lung cancer.

关 键 词：癌 非小细胞肺 肺外科手术 老年人 手术后并发症 预后 

分 类 号：R734.2[医药卫生—肿瘤]