钙信号重构调控肿瘤发生发展  

Dysregulation of Calcium Signaling in Tumor Formation and Progression

作　　者：孙翠巍[1] 王显花[1] 程和平[1] 

机构地区：[1]北京大学分子医学研究所,北京100871

出　　处：《生物化学与生物物理进展》2014年第10期1010-1017,共8页Progress In Biochemistry and Biophysics

摘　　要：钙离子是细胞内最重要的第二信使之一,对肿瘤细胞的发生发展起着重要的调控作用.无节制的增殖、降低的凋亡和高度的转移能力是肿瘤细胞的三大特征.细胞过度增殖需要胞浆钙升高,而逃避凋亡则需要较低的胞浆钙.在肿瘤发生发展过程中,早期过表达的胞膜钙通道倾向于调低,而内质网钙通道表达升高,并伴有通道定位的改变和新通道的形成.迁移细胞中的微区钙信号可决定细胞转移的方向.综上所述,钙信号可作为药物靶点,在肿瘤药物研发中具有一定的潜力.Calcium ion plays vital roles in virtually all aspects of cell physiology and biology. Dysregulation of calcium homeostasis emerges as an important hallmark for tumor cells. Remodeling in the expression, activities, and localizations of calcium channels and transporters is common to tumor progression. Elevated intracellular calcium prompts uncontrolled growth during tumor formation, whereas lowered calcium appears to be anti-apoptotic in the later phase of tumor progression. Moreover, local and global calcium oscillations may facilitate and guide cell migration in metastasis. These recent advances suggest that targeting calcium signaling may afford potential therapeutic strategies to intervene the tumor formation and progression.

关 键 词：钙信号 肿瘤 增殖 凋亡 迁移 

分 类 号：R73[医药卫生—肿瘤]