喜炎平注射液对比格犬心电图的影响  

Effects of Xi Yanping injection on electrocardiogram of Beagle dogs

作　　者：齐卫红[1] 王超[1] 李欣[1] 张琳[1] 刘运强 李伟[1] 

机构地区：[1]中国食品药品检定研究院,北京100050 [2]江西青峰药业有限公司,江西赣州341000

出　　处：《中国比较医学杂志》2014年第9期14-17,共4页Chinese Journal of Comparative Medicine

基　　金：国家"重大新药创制"科技重大项目(2012ZX09302001)

摘　　要：目的研究喜炎平注射液对比格犬心电图的影响。方法将24只比格犬随机分为阴性对照组(0mg/kg)、低剂量组(15 mg/kg)、中剂量组(75 mg/kg)、高剂量组(250 mg/kg),每组6只,雌雄各半。每天一次,连续28 d静脉点滴喜炎平注射液,给药体积是20 mL/kg,并设置恢复期14 d。测定不同时期Ⅱ导联心电图。计算心率、P-R间期、Q-T间期、P波振幅、Q波振幅、R波振幅、S波振幅、ST振幅、T波振幅等指标,并同期取血测定血清生化学指标,观察对主要脏器的影响。结果检疫期,24犬心电图各项指标均在正常值范围之内。高剂量组P-R间期时间延长。给药中期,给药结束后及恢复期各项指标未见异常。结论喜炎平注射液对比格犬心电图无明显影响。Objective To study the effect of Xi Yanping injection on electrocardiogram in Beagle dogs.Methods 24 Beagle dogs were divided into negative control group （0 mg/kg）, low-dose group （15 mg/kg）, middle-dose group （75 mg/kg）, high-dose group （250 mg/kg）.Each group consist of 3 animals/sex/group, all animals were administrated by intravenous drip at 20 mL/kg once a day.Administration period was 28-days with 14-days recovery phase.Animals LeadⅡelectrocardiogram （ ECG） was measured during quanrantine, administration and recovery phase.The following parameters included heart rate, P -Rinterval, Q -T interval, P, Q, RS wave amplitude and ST and T wave amplitude were determined, serum biochemical parameters were measured to evaluate the effect on main organs.Results All parameters of quarantine period were fell in the normal limit.After the first administration, heart rate decrease was found in low dose group and P-Rinterval prolongation was found in high dose group.No abnormal was found in dose metaphase,end of dose stage and recovery stage.Conclusion Xi Yanping injection had no obvious influence on ECG of Beagle dog.

关 键 词：喜炎平注射液 比格犬 心电图 

分 类 号：R332[医药卫生—人体生理学]