羟基磷灰石晶须抗菌改性的工艺研究  

The study of antibacterial modification of hydroxyapatite whisker

作　　者：金建烽 王刚[2] 张文云[2] 陈庆华[3] 郝爱连 刘文英 

机构地区：[1]昆明市口腔医院综合科,云南昆明650110 [2]成都军区昆明总医院口腔科,云南昆明650031 [3]昆明理工大学材料科学与工程学院材料物理与化学系,云南昆明650093

出　　处：《口腔医学》2014年第10期725-729,共5页Stomatology

基　　金：国家自然科学基金资助项目(81260272)

摘　　要：目的探讨纳米氧化锌(ZnO)在不同pH值和温度下改性-羟基磷灰石晶须(HAPw)的工艺研究。方法在pH=6.4或6.6,温度为37℃或70℃条件下,醋酸锌溶胶-凝胶法改性羟基磷灰石晶须,经搅拌、超声、旋转、干燥、焙烧得白色粉末,应用透射电镜、扫描电镜和X射线能量色散谱方法分析。结果当pH=6.4,温度为70℃时,ZnO-HAPw复合体形貌为颗粒状;当pH=6.6,温度为70℃时,ZnO-HAPw复合体形貌为三角形状;当pH=6.6,温度为37℃时,ZnO-HAPw复合体形貌为短棒状或锣钉状,X射线能量色散谱方法分析晶须表面复合物为ZnO。结论醋酸锌溶胶-凝胶法可改性羟基磷灰石晶须表面。不同温度和pH值下可形成不同形貌ZnO-HAPw复合体。Objective To explore the preparation of several kinds of morphologies of ZnO -HAPw with different temperatures and pH values. Methods Hydroxyapatite whisker was modified by Zinc acetate via sol-gel,which was stirred, concussed,spun and annealed, and then white powder was obtained. At last,it was analyzed by transmission electron microscopy scanning electron microscope and en- ergy dispersive X-ray spectroscopy. Results Four kinds of morphologies of ZnO-HAPw were granule, triangle,short rod and gongs nail at pH = 6.4 and 70 ℃ ,pH = 6.6 and 70 ℃ ,pH = 6.6 and 37 ℃ , pH = 6.6 and 37 ℃ respectively. It was demonstrated that the sub- stance on the whisker surface was ZnO by analyzing energy dispersive X-ray spectroscopy. Conclusions Hydroxyapatite whisker could be modified by Zinc acetate via sol-gel. And different morphologies of ZnO-HAPw can be produced with different temperatures and pH values.

关 键 词：氧化锌 羟基磷灰石晶须 溶胶-凝胶法 改性 形貌 

分 类 号：R783.1[医药卫生—口腔医学]