Foxp3-924基因多态性与变应性结膜炎关系探讨  

Study on Foxp3——924 polymorphisms in patients with allergic conjunctivitis

作　　者：杨瑞明[1] 赖荷[1] 沙翔垠[1] 陈盛强[1] 谭颖谦[1] 刘志平[1] 郑瑜[1] 陈卫芳[1] 

机构地区：[1]广州医科大学附属第二医院眼科,广东510260

出　　处：《中国实用眼科杂志》2014年第10期1187-1190,共4页Chinese Journal of Practical Ophthalmology

基　　金：广东省科技计划基金资助项目（20108031600139）

摘　　要：目的 对尘螨诱导引起变应性结膜炎的患者行Foxp3-924 （rs2232365）基因分型,探讨Foxp3-924 （rs2232365）基因与尘螨变应性结膜炎遗传易感性的相关性.方法 临床对照研究.对2007～2011年在广州医科大学附属第二医院眼科应用PCR-SSP技术为80例无亲缘关系的尘螨变应性结膜炎患者和103名无血缘关系的健康汉族人行Foxp3-924 （rs2232365）基因分型.结果 Foxp3-924位点AA基因型频率在变应性结膜炎患者与正常对照组相比差异无统计学意义[32.5％ （26/80） vs.23.3％ （24/103）,x 2=1.92,P＞0.05）;GA基因型在变应性结膜炎患者中的频率显著高于正常对照组,差异有统计学意义（x2=4.82,P＜0.05）.GG基因型在变应性结膜炎患者中的频率显著低于正常对照组,差异有统计学意义（x2=11.78,P＜0.01）.与正常人相比,Foxp3-924 A等位基因频率显著上升,G等位基因下降,差异有统计学意义（x2=9.77,P＜0.01）.结论 Foxp3-924位点基因多态性与变应性结膜炎显著相关.Objective To investigate the distribution of Foxp3-924（rs2232365）genes in a Guangdong population and to explore the association of these genes with allergic conjunctivitis.Methods A total of 103 unrelated healthy individuals of Han nationality and 80 patients with allergic conjunctivitis who were from the same geographic region were enrolled in the study.Foxp3-924（rs2232365） was genotyped by PCR-SSP technique.Results There was no significant difference of Foxp3-924 AA genotype frequencies between the patients with allergic conjunctivitis and the normal control group（32.5% vs.23.3%,x2=1.92,P 〉0.05）.The frequencies of GA genotype in the patients with allergic conjunctivitis were significantly higher than the normal control group（x2=4.82,P 〈0.05）.And the frequencies of GG genotype in the patients with allergic conjunctivitis were significantly lower than the normal control group（x2=11.78,P 〈0.01）.Compared to the normal control group,the frequencies of Foxp3-924 A allele were significantly increased while the G allele was reduced significantly（x2=9.77,P 〈0.01）.Conclusions Foxp3-924（rs2232365）is associated with allergic conjunctivitis.

关 键 词：尘螨 变应性结膜炎 Foxp3-924 (rs2232365) 多态性 

分 类 号：R777.31[医药卫生—眼科]