延长扫描时间和大剂量对比剂对肝硬化患者门静脉期CT图像质量的影响  

Effect of large contrast agent dose and prolong scanning time on the image quality of CT portal venous phase images in patients with liver cirrhosis

作　　者：鲁慧[1] 杨剑[2] 

机构地区：[1]香港大学深圳医院医学影像科放射医学中心,518000 [2]深圳市蛇口人民医院消化内科

出　　处：《实用医学影像杂志》2014年第5期314-317,共4页Journal of Practical Medical Imaging

摘　　要：目的探讨大剂量对比剂及延长扫描时间对肝硬化患者门静脉期CT图像质量的影响。方法选取75例肝硬化患者,其中采用常规时间常规剂量扫描(60 s,1.5 ml/kg)患者为对照组(25例),延长扫描时间(70 s)患者为延长组(25例),在延长扫描时间的基础上增加对比剂剂量(2.5 ml/kg)患者为大剂量组(25例),不同延长扫描时间和不同扫描剂量肝静脉、肝实质、门静脉强化峰值、平均强化峰值时间与图像质量双盲目测评分值的差异。结果延长扫描时间后,延长组肝静脉、肝实质、门静脉强化峰值、静脉与肝实质差值、图像质量评分为(206.4±3.6)Hu、(110±13)Hu、(188±13)Hu、(74±11)Hu、(3.0±1.2)分,均明显高于对照组,肝实质、门静脉平均强化峰值时间明显低于对照组,2组比较差异具有统计学意义(P<0.05);在延长扫描时间的基础上增大对比剂剂量后,大剂量组上述指标分别为(218±11)Hu、(115±14)Hu、(214±16)Hu、(86±13)Hu、(3.6±0.7)分、(63.8±2.9)s、(44±5)s,均明显优于延长组,2组比较差异具有统计学意义(P<0.05)。结论延长扫描时间(70 s)和增加对比剂剂量(2.5 ml/kg)在一定程度上改善肝硬化患者门静脉期CT图像质量,有利于获取更清晰的CT图像。Objective To discuss effect of large contrast agent dose and prolonged scanning time on the image quality of CT portal venous phase images in patients with liver cirrhosis. Methods Seventy-five cases of liver cirrho-sis were divided into three groups, which used the conventional time and dose scan （60 s, 1.5 ml/kg） were chosen as control group （25 cases）, prolonged scanning time （70 s） and conventional dose scan were as prolonged group （25 cases）, high dose （2.5 ml/kg） and prolonged scanning time were as high dose group （25 cases）. The hepatic vein, portal vein, hepatic parenchyma peak enhancement and image quality in double blind evaluation values were compared. Results By extending scanning time, hepatic vein, portal vein, hepatic vein, liver parenchyma peak enhancement, image quality score of prolonged group were （206.4±3.6） Hu, （110±13） Hu, （188±13） Hu, （74±11） Hu, （3.0±1.2） score, significantly higher than control group, the average time to peak enhancement in liver parenchyma, portal vein were significantly lower than the control group （P〈0.05）. By increasing the dose of contrast agent and extended scanning time above indexes of high dose group were （218±11） Hu, （115±14） Hu, （214±16） Hu, （86±13） Hu, （3.6±0.7） score, （63.8±2.9） s, （44±5） s, which were better than those of prolonged group （P〈0.05）. Conclusion Prolonging scanning time （70 s） and increasing the dose of contrast agent （2.5 ml/kg） can improve the image quality of CT in portal venous phase of liver cirrhosis in a certain extent, which can be conductive to the acquisition of CT image, and make it more clearly.

关 键 词：肝硬化 门静脉造影术 体层摄影术 螺旋计算机 

分 类 号：R575.2[医药卫生—消化系统] R816.5[医药卫生—内科学]