Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy  

作　　者：Xiang-Yu Su Pei-Dang Liu Hao Wu Ning Gu 

机构地区：[1]Department of Oncology, Zhongda Hospital of Southeast University [2]Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University

出　　处：《Cancer Biology & Medicine》2014年第2期86-91,共6页癌症生物学与医学（英文版）

基　　金：supported by the National Key Basic Research Program of China (973 Program) (Grants No. 2013CB933904 and 2011CB933500)

摘　　要：Radiation therapy performs an important function in cancer treatment. However, resistance of tumor cells to radiation therapy still remains a serious concern, so the study of radiosensitizers has emerged as a persistent hotspot in radiation oncology. Along with the rapid advancement of nanotechnology in recent years, the potential value of nanoparticles as novel radiosensitizers has been discovered. This review summarizes the latest experimental findings both in vitro and in vivo and attempts to highlight the underlying mechanisms of response in nanoparticle radiosensitization.Radiation therapy performs an important function in cancer treatment. However, resistance of tumor cells to radiation therapy still remains a serious concern, so the study of radiosensitizers has emerged as a persistent hotspot in radiation oncology. Along with the rapid advancement of nanotechnology in recent years, the potential value of nanoparticles as novel radiosensitizers has been discovered. This review summarizes the latest experimental findings both in vitro and in vivo and attempts to highlight the underlying mechanisms of response in nanoparticle radiosensitization.

关 键 词：Nanoparticles radiation tolerance cancer radiotherapy 

分 类 号：R730.55[医药卫生—肿瘤]