Breast metastasis from lung cancer：a report of two cases and literature review  

作　　者：Li Wang Shu-Ling Wang Hong-Hong Shen Feng-Ting Niu Yun Niu 

机构地区：[1]Department of Breast Cancer Pathology and Research Laboratory [2] Key Laboratory of Breast Cancer Prevention and Therapy~Tianjin Medical University, Ministry of Education [3] Key Laboratory of Cancer Prevention and Therapy, Tianjin [4] Tianjin MedicaUniversity Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin 30060, China

出　　处：《Cancer Biology & Medicine》2014年第3期208-215,共8页癌症生物学与医学（英文版）

基　　金：supported by the National Natural Science Foundation of China （Grant No.81172532）; the Program for Changjiang Scholars and Innovative Research Team in University （Grant No.TRT0743）

摘　　要：Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4% to 1.3% has been reported in literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant melanoma. In this report, two cases of pulmonary metastasis to the breast were presented. A 40-year-old female manifested a right breast mass of 2-month duration. After physical examination was performed, a poorly defined mass was noted in the upper outer quadrant of the right breast. Another 49-year-old female manifested right breast mass of 5-day duration. A poorly defined mass was noted in the lower inner quadrant of the right breast. Mammography results also revealed breast cancer. The patients underwent local excision. After histological and immunohistochemical analyses were conducted, a primary lung carcinoma that metastasized to the breast was diagnosed. An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4% to 1.3% has been reported in literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant melanoma. In this report, two cases of pulmonary metastasis to the breast were presented. A 40-year-old female manifested a right breast mass of 2-month duration. After physical examination was performed, a poorly defined mass was noted in the upper outer quadrant of the right breast. Another 49-year-old female manifested right breast mass of 5-day duration. A poorly defined mass was noted in the lower inner quadrant of the right breast. Mammography results also revealed breast cancer. The patients underwent local excision. After histological and immunohistochemical analyses were conducted, a primary lung carcinoma that metastasized to the breast was diagnosed. An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.

关 键 词：Lung cancer breast metastasis immunohistochemistry thyroid transcription factor-1（TTF1） 

分 类 号：R734.2[医药卫生—肿瘤] R737.9[医药卫生—临床医学]