复方川芎滴丸的质量控制研究  

Quality control on Compound Chuanxiong Rhizoma Pills

作　　者：肖婷[1] 崔炯谟[1] 安晔[2] 马宏达[2] 郭正红[3] 史国兵[2] 赵余庆[3,4] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]沈阳军区总医院,辽宁沈阳110016 [3]沈阳药科大学中药学院,辽宁沈阳110016 [4]基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《药物评价研究》2014年第5期427-430,共4页Drug Evaluation Research

基　　金：军队医疗机构制剂标准提高科研专项重点课题(13ZJZ02)

摘　　要：目的建立复方川芎滴丸的质量标准。方法采用薄层色谱法对复方中当归、川芎进行了定性鉴别,采用高效液相色谱法对当归、川芎中阿魏酸进行了定量测定。结果薄层色谱分离度好;阿魏酸在0.001~0.100 mg/mL与峰面积线性关系良好,平均回收率为102.06%,RSD值为2.25%（n=6）。结论所建立的方法准确可靠,灵敏度高,专属性强,可有效控制复方川芎滴丸的质量。Objective To establish the quality standard for Compound Chuanxiong Rhizoma Pills. Methods TLC method was performed to identify Angelica sinensis, Rhizoma Chuanxiong in Compound Rhizoma Chuanxiong Pills and HPLC was used to determine the content of ferulic acid in Angelica sinensis and Chuanxiong Rhizoma. Results TLC had good resolution and specificity. The ferulic acid showed a good liner relationship within the range of 0.001--0.1 mg/mL. The average recovery rate was 102.06% with RSD of 2.25%. Conclusion The method is accurate, specific, and could be used for the quality control of Compound Chuanxiong Rhizoma Pills.

关 键 词：复方川芎滴丸 阿魏酸 薄层色谱法 高效液相色谱法 

分 类 号：R917.4[医药卫生—药物分析学]