食管肉瘤样癌的临床特征与病理对照研究  

Comparative study on clinical characteristics and pathology of esophageal sarcomatoid carcinoma

作　　者：王洪云[1] 候庆宝 曹慧[1] 

机构地区：[1]山东省胸科医院,250013

出　　处：《中国实用医药》2014年第29期30-31,共2页China Practical Medicine

摘　　要：目的探讨食管肉瘤样癌的临床病理特点及手术治疗后患者预后情况。方法回顾性分析25例经手术治疗的食管肉瘤样癌患者的临床及病理资料。结果临床症状:进行性吞咽困难,伴有胸骨后疼痛。CT显示:肿瘤向食管腔内突起性生长,主要发生在食管中、下段。免疫组化:25例肿瘤癌成分中,细胞角蛋白,上皮膜抗原均阳性表达。本组病例1、3、5年生存率分别为84%、60%、44%。3年生存率两两对比,差异均具有统计学意义(P<0.05)。结论食管肉瘤样癌的瘤组织由癌成分与肉瘤样成分混合组成,呈多样性,具有移行分化的潜能,对于该肿瘤淋巴结转移较少、外侵不明显者,手术切除+放化疗及适当靶向药物治疗通常能获得较好的治疗效果。Objective To study the clinical characteristics of esophageal sarcomatoid carcinoma, and prognosis of patients after surgery. Methods Retrospective analysis was made of clinical and pathological data of 25 cases undergone surgical operation treatment of esophageal sarcomatoid carcinoma. Results The clinical symptoms were progressive dysphagia, accompanied by retrosternal pain. CT showed that protuberant tumor grew in the esophageal lumen, mainly in the middle and lower segment of esophagus. Immunohistochemistry showed that cytokeratin and epithelial membrane antigen expressions were positive in carcinoma components of 25 cases of tumor. Survival rates of 1-year, 3-year, and 5-year were 84%, 60%, 44% of these cases. The comparison of the survival rates had significant difference （P〈0.05）. Conclusion Esophageal sarcomatoid carcinoma tissue is composed of carcinoma component and sarcomatoid components. It has diversity and transitional differentiation. The lymph node metastasis is few, and not obvious. Surgical resection combined with chemotherapy and proper targeting drug treatment usually can provide good therapeutic effects.

关 键 词：食管 肉瘤样癌 外科学 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]