氩氦刀联合放疗治疗晚期EGFR野生型非小细胞肺癌合并慢性阻塞性肺疾病患者的临床观察  

The effect of sequentially combined therapy with cryosurgery and radiotherapy in treating EGFR wild-type advanced NSCLC patients

作　　者：周承志[1] 秦茵茵[1] 张洁霞[1] 蒋昌斌[2] 陈愉[1] 邓宇[3] 欧阳铭[1] 李时悦[1] 陈荣昌[1] 

机构地区：[1]呼吸疾病国家重点实验室,呼吸疾病国家临床研究中心,广州医科大学附属第一医院广州呼吸疾病研究所,广东广州510120 [2]广州医科大学附属第一医院放疗科,广东广州510120 [3]广州医科大学附属第一医院放射科,广东广州510120

出　　处：《现代肿瘤医学》2014年第11期2600-2603,共4页Journal of Modern Oncology

基　　金：国家青年自然科学基金项目(编号:81100035);广东省科技计划项目(编号:2012B031800237)

摘　　要：目的:探讨氩氦刀联合放疗一线治疗晚期EGFR野生型非小细胞肺癌合并慢性阻塞性肺疾病(COPD)患者的近期疗效。方法:对26例EGFR野生型合并COPD的肺癌患者在一线化疗的基础上对胸部不同部位病灶合理利用放疗和氩氦刀联合治疗。对中央病灶或纵隔转移淋巴结实行姑息性三维适行放疗(3DCRT),而对周围肺部病灶行经皮穿刺氩氦刀冷冻消融治疗,观察其近期治疗效果和不良反应。结果:26例患者经过联合治疗后,一线有效率达到42.31%,疾病控制率(DCR)为80.77%,近期疗效并不弱于PS评分好的晚期肺癌患者。所有患者的不良反应均为Ⅰ到Ⅱ级,经处理后都能完成整个治疗过程。结论:对于晚期EGFR野生型非小细胞肺癌合并慢性阻塞性肺疾病患者,设计个体化方案,通过合理利用化疗、放疗、氩氦刀能取得较好的疗效。Objective：To explore the effect of sequentially combined therapy with cryosurgery,radiotherapy and chemotherapy in treating EGFR wild-type NSCLC patients.Methods：Sequentially combined therapy with cryosurgery,radiotherapy and chemotherapy in treating some certain kind of NSCLC patients.The recently therapeutic effect and adverse reactions were observed.Results：All 26 patients completed the whole treatment.The objective response rate was 42.31% and disease control rate 80.77% almost the same as those patients with good PS score.All patients＇ adverse reactions were lever Ⅰ to Ⅱ.Conclusion：Reasonable combination with cryosurgery,radiotherapy and chemotherapy in treating some certain kind of patients with poor PS score can get the good response.

关 键 词：NSCLC EGFR野生型 冷冻消融 放疗 

分 类 号：R734.2[医药卫生—肿瘤]