联合检测血清肿瘤标志物对原发性肝癌患者诊断和治疗的临床应用价值  

The clinical value of combined detection of serum tumor markers for diagnosis and treatment of primary hepatic carcinoma

作　　者：张红 赵花 张琰 白晓 

机构地区：[1]武警陕西省总队医院检验科,陕西西安710054 [2]武警陕西省总队医院病理科,陕西西安710054

出　　处：《现代肿瘤医学》2014年第11期2684-2686,共3页Journal of Modern Oncology

摘　　要：目的:探讨肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、CA199、谷氨酸氨基转肽酶(GGT)联合检测对原发性肝癌(PHC)患者诊断及治疗的临床意义。方法:应用化学发光法及全自动生化分析仪对80例原发性肝癌患者和50例肝病患者及70例健康体检者进行AFP、CEA、CA199、GGT检测。结果:原发性肝癌组AFP、CEA、CA199、GGT各项指标均显著高于肝病组和健康体检组,差异具有统计学意义(P<0.01)。联合检测的灵敏度和特异度分别为94.61%、80.75%,与单项检测比较阳性率明显增高,差异具有统计学意义(P<0.05)。结论:血清AFP、CEA、CA199、GGT联合检测可提高原发性肝癌诊断的敏感性,对早期诊断原发性肝癌具有一定的临床应用价值。Objective：To investigate the clinical significance of combined detection of serum tumor markers,alpha fetal protein （AFP）,carcinoembryonic antigen （CEA）,carbonydrate antigen （CA199）,glutamyl transpeplidase （GGT）,in diannosis and treatment of primary hepatic carcinoma （PHC）.Methods：The level of AFP,CEA,CA199 and GGT was examined by chemiluminescence and automatic biochemical analyzer in 80 patients with PHC,50 patients with liver disease and 70 healthy persons.Results：The levels of AFP,CEA,CA199 and GGT,of the PHC were significantly higher than that of liver disease group and healthy persons,the difference was statistically significant（P 〈 0.01）,the sensitivity and specificity of combined test were 94.61%,and 80.75%,respectively.Compared with single test positive rate increased obviously and the difference was statistically significant （P 〈 0.05）.Conclusion：Combined detection of AFP,CEA,CA199,GGT in serum can improve the sensitivity of the PHC diagnosis,and for early diagnosis has certain clinical value.

关 键 词：原发性肝癌 甲胎蛋白(AFP) 癌胚抗原(CEA) CA199 谷氨酸氨基转肽酶(GGT) 

分 类 号：R735.7[医药卫生—肿瘤]