老年男性非酒精性脂肪肝患者血清胎球蛋白A水平的变化  

Serum fetuin-A level in non-alcoholic fatty liver disease in elderly male

作　　者：陶婷[1] 吴霖[1] 谢雨苏 吴方[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院老年病科,上海200025 [2]徐汇区龙华街道社区卫生服务中心,上海200232

出　　处：《内科理论与实践》2014年第5期325-327,共3页Journal of Internal Medicine Concepts & Practice

摘　　要：目的:研究老年男性非酒精性脂肪肝(NAFLD)患者血清胎球蛋白A水平的变化。方法:选择年龄≥60岁的老年男性,根据中华医学会肝脏病学分会制定的标准判断是否存在NAFLD,依据病史排除酒精性脂肪肝及病毒性肝炎。入选NAFLD组52例,年龄、体质量指数与NAFLD组匹配的肥胖非NAFLD组70例(配对组),非肥胖非NAFLD组62例(对照组)。采用酶联免疫法测定血清胎球蛋白A水平及生化指标。结果:NAFLD组的丙氨酸转氨酶、天冬氨酸转氨酶、γ谷氨酰转肽酶(GGT)、三酰甘油、空腹胰岛素、胰岛素抵抗指数均高于配对组、对照组(P<0.05)。NAFLD组空腹血胎球蛋白A水平高于配对组及对照组(P<0.05)。空腹血胎球蛋白A水平与空腹胰岛素水平及胰岛素抵抗指数正相关(r=0.168,r=0.161;均P<0.05)。结论:老年男性NAFLD患者血清胎球蛋白A水平升高,其可能的机制与血清胎球蛋白A所致胰岛素抵抗有关。Objective To study the change of serum fetuin-A level in non-alcoholic fatty liver disease （NAFLD） in elderly males. Methods The elderly males （≥60 years） were enrolled and divided into three groups： NAFLD group （n= 52）, matched group （fatty but without fatty liver disease whose age, body mass index were matched with NAFLD group） （n= 70）, control group （without fatty and NAFLD） （n=62）. Serum level of fetuin-A and biochemical indices were measured by enzyme linked immunoassay （ELISA）. Results Aspartate aminotransferase （AST）, alanine aminotransferase （ALT）,gamma- glutamyl transpeptidase （GGT）, triglyceride （TG）, fast insulin and homeostasis model assessment for insulin resistance （HOMA-IR） in NAFLD group were higher than that in matched group and control group （P〈0.05）. The serum fetuin-A level in NAFLD group was higher than that in matched group and control group （P〈0.05）. Fetuin-A level was positively correlated with fast insulin level and HOMA-IR. Conclusions These data showed that serum level of fetuin-A in NAFLD elderly male was increased and the possible mechanism might be related with insulin resistance.

关 键 词：非酒精性脂肪肝 胎球蛋白A 胰岛素抵抗 老年男性 

分 类 号：R575.5[医药卫生—消化系统]