后程加速超分割三维适形放疗食管癌的疗效与不良反应分析  

Effectiveness and Adverse Reactions of Latecourse Accelerated Fractionation Radiotherapy Combined with Three-dimensional Conformal Radiotherapy for Esophageal Carcinoma

作　　者：颜金明 

机构地区：[1]浙江省肿瘤医院,杭州310022

出　　处：《医学研究杂志》2014年第10期139-141,共3页Journal of Medical Research

摘　　要：目的 探讨后程加速超分割三维适形放疗食管癌的疗效与不良反应.方法 对笔者医院2010年3月～2013年3月期间收治的两组共160例食管癌患者,分为对照组和观察组,观察组行三维适形放疗和后程加速超分割联合治疗,放疗组采用后程加速超分割放疗法,对两组患者的疗效和治疗方法的安全性进行评价.结果 观察组治疗有效率（RR）达到90.0％,对照组治疗有效率为72.5％,两组比较具有统计学差异（P＜0.05）.观察组患者3年局部控制率和生存率为分别为67.5％（54/80）和52.5％（42/80）,对照组为42.5％（34/80）和35.0％（28/80）,两组比较具有统计学差异（P＜0.05）.对照组急性放射性食管炎及气管炎的不良反应发生率为82.5％和62.5％,观察组为55.0％和45.0％.结论 后程超分割三维适形放疗对于局部食管癌患者近期疗效及生存率均有提高,并且较常规后程超分割疗法引发较轻的不良反应.Objective To study the effectiveness and adverse reactions of LCAFR combined with 3DCRT for esophageal carcinoma.Methods There were 160 cases of esophageal carcinoma patients in our hospital between March 2007 and March 2009.They were divided into the observation group and control group.The observation group was treated with the LCAFR and 3DCRT.The control group was only treated with LCAFR.The efficacy and the safety of the patients were evaluated.Results The treatment efficiency of the observation group was 90.0%,and the control group was72.5%.They had significant difference（P 〈 0.05）.The local control and survival rate of observation group in 3 years were 67.5% （54/80） and 67.5% （42/80）.The control group was 42.5% （34/80） and 35.0% （28/80）.The two groups had significant difference（P 〈 0.05）.The adverse reactions including esophagitis and bronchitis of control group were 82.5% and 62.5%.The observation group was 55.0% and 45.0%.Conclusion The local control and survival rateof LCAFR and 3DCRT was efficient and adverse reactions did not increase obviously.

关 键 词：食管癌 三维适形放疗 后程加速超分割 不良反应 

分 类 号：R73[医药卫生—肿瘤]