肝细胞癌早期诊断血清学标志物的研究进展  

Research advances in serum biomarkers for early diagnosis of hepatocellular carcinoma

作　　者：朱明玉[1] 陈洁[1] 张欣欣[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院感染科,上海200025

出　　处：《临床肝胆病杂志》2014年第10期1091-1093,共3页Journal of Clinical Hepatology

基　　金：国家国际科技合作项目(S2012GR0046)

摘　　要：肝细胞癌(HCC)是一种发生率和致死率均较高的严重威胁人类健康的疾病。目前尚无一种血清学指标可以单独早期诊断HCC。总结了近年发现对HCC早期诊断有潜在价值的血清学标志物,并对其在诊断HCC的敏感性和特异性以及判断疾病进展等方面进行阐述,认为对HCC早期诊断应通过联合其他血清学标志物以弥补甲胎蛋白在敏感性方面的不足。Hepatocellular carcinoma （HCC）is a disease with high incidence and mortality and has become a serious threat to human health. So far,none of the available markers can be used alone for early diagnosis of HCC.Recently identified serum markers with potential clinical value for early diagnosis of HCC are summarized,and their diagnostic sensitivity and specificity,as well as their applications in assessment of progression of the disease,are reviewed.It is suggested that alpha -fetoprotein should be used in combination with other serum markers to achieve accurate diagnosis of HCC at early stages.

关 键 词：癌 肝细胞 早期诊断 血清学标志物 综述 

分 类 号：R735.7[医药卫生—肿瘤]