中等强度有氧运动对阿尔茨海默病患者认知和运动功能的影响  

The effect of aerobic exercise of middle intensity on cognitive and motor functions of patients with Alzheimer＇s disease

作　　者：王石艳 朱奕 张勤 范亚蓓 孙建国[2] 吴婷[2] 王彤 

机构地区：[1]南京医科大学第一附属医院康复医学中心,南京210029 [2]南京医科大学第一附属医院神经内科,南京210029

出　　处：《中华物理医学与康复杂志》2014年第10期765-768,共4页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：江苏省科技支撑计划——社会发展基金（BE2013724）

摘　　要：目的 探讨中等强度的有氧运动对于阿尔茨海默病（AD）患者功能改善的干预作用.方法 将AD患者48例按随机数字表法分为有氧运动组和对照组,每组24例.有氧运动组采用踩功率车运动;对照组只接受宣传教育,未参与有氧运动.有氧运动组于治疗前和治疗3个月后（治疗后）进行运动能力和认知功能的评估,对照组在上述时间点仅进行认知功能的评估.结果 治疗前,2组患者间的简易精神状态评分（MMSE）和阿尔茨海默病评定量表认知部分（ADAS-Cog）总分组间比较,差异均无统计学意义（P＞0.05）.治疗后,有氧运动组患者MMSE和ADAS-Cog总分分别为（21.10±4.17）分、（19.57±11.38）分,分别与组内治疗前和对照组治疗后比较,差异均有统计学意义（P＜0.05）.结论 中等强度的有氧运动可以改善AD患者认知和运动功能.Objective To evaluate the effects of aerobic exercise of middle intensity on cognitive and motor functions of elderly people with Alzheimer＇s disease （AD）.Methods Forty-eight patients with AD were studied.The subjects were randomly divided into a treatment group and a control group.The subjects in treatment group were treated with cycle ergometer exercise for 3 months.The control group accepted dementia education.All the patients performed the mini-mental state examination （MMSE） and Alzheimer＇s disease assessment scale-cognitive subscale （ADAS-Cog） at the beginning and after 3 months of treatment.Results Forty-one participants completed the whole treatment and observation program.After treatment,the scores of MMSE and ADAS-Cog improved significantly more in treatment group than those in control group （P ＜ 0.05）.Conclusion Middle intensity of aerobic exercise can improve cognitive and motor function in patients with AD.

关 键 词：有氧运动 阿尔茨海默病 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]