多巴胺D_2受体基因TaqIA多态性与中国汉族人群海洛因依赖的Meta分析  

Association of D_2 dopamine receptor gene Taq IA polymorphisms with heroin dependence in Chinese Han population:a meta-analysis

作　　者：胡佩武 李杏莉[1] 罗希[1] 刘志胜[1] 刘姝[1] 汤学 

机构地区：[1]中南大学公共卫生学院流行病与卫生统计学系,长沙410078

出　　处：《中国神经精神疾病杂志》2014年第9期536-541,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金项目(编号:81202257);中南大学教师研究基金项目(编号:2013JSJJ032);教育部留学归国人员科研启动基金(编号:第47批)

摘　　要：目的系统评价多巴胺D2受体基因raqIa多态性与中国汉族人群海洛因依赖的相关性。方法检索中国知网、万方、维普、PubMed、Embase等中外数据库于建库至2014年4月公开发表的文献，收集有关多巴胺D：受体基因TaqlA多态性与中国汉族人群海洛因依赖的病例对照研究进行Meta分析。结果共纳入10项病例对照研究，包括2823例患者与2502名对照。Meta分析结果显示，A1/A2等位基因（OR=1．28，95％CI：1．05-1．56）、A1A1/A2A2基因型（OR=1．54，95％CI：1．00～2．36）、A1A1／（A1A1＋A2A2）基因型（OR=1．54，95％CI：1．09—2．17）均与海洛因依赖有关。基于地域的亚组分析显示，多巴胺D2受体基因TaqlA多态性可增加大陆地区汉族人群海洛因依赖的风险[A1A1／A2A2（OR：1．66，95％CI：1．37。2．02）]，而与台湾汉族人群海洛因依赖风险无统计学关联[A1A1／A2A2（OR：0．81，95％CI：0．57-1．15）1。结论多巴胺D2受体基因TaqlA多态性与中国汉族人群海洛因依赖存在关联，携带有A1等位基因是海洛因依赖的危险因素。Objective To explore the association between D2 dopamine receptor gene TaqlA polymorphism and heroin dependence in Chinese Han population. Methods Relevant articles were searched from CNKI, Wanfang database, PubMed, Embase and other foreign databases until April 2014. Meta-analysis was conducted on case-control studies on D2 dopamine receptor gene TaqIA polymorphism with heroin dependence in Chinese Han population using Stata 12.0 software. Results Ten case-control studies on association between DE dopamine receptor gene TaqIA polymorphism and heroin dependence were retrieved from the databases including 2823 heroin dependence patients and 2502 controls. The frequencies of A1/A2 allele （OR=1.28, 95% CI. 1.05-1.56）, genotype A1A1/A2A2 （OR=1.54, 95% CI： 1.00-2.36） and genotype A1A1/（A2A2＋ A2A2） （OR=1.54, 95%CI： 1.09-2.17） were associated with heroin dependence. Subgroup analysis grouped by region showed that D2 dopamine receptor gene TaqIA polymorphism increased the risk of heroin dependence in Chinese mainland population [AIA1/A2A2 （OR=1.66, 95%CI： 1.37-2.02）]. However, there was no association between TaqlA polymorphism and the risk of heroin dependence in Taiwan population [A1A1/A2A2 （OR=0.81, 95% CI ： 0.57- 1.15）]. Conclusion D2 dopamine receptor gene TaqlA polymorphism is associated with heroin dependence in Chinese

关 键 词：多巴胺D2受体 基因多态性 海洛因依赖 META分析 

分 类 号：R749.64[医药卫生—神经病学与精神病学]