代谢综合征及其组分与子宫内膜样腺癌患者预后的关系  

Association between metabolic syndrome and prognosis of endometrioid carcinoma

作　　者：倪镌[1] 楼寒梅[1] 朱滔[1] 赵灵琴[1] 寿华锋[1] 

机构地区：[1]浙江省肿瘤医院妇瘤科,杭州310022

出　　处：《中华妇产科杂志》2014年第10期768-771,共4页Chinese Journal of Obstetrics and Gynecology

基　　金：浙江省医药卫生科学研究基金（2013KYB045）

摘　　要：目的 探讨代谢综合征（MS）及其组分与子宫内膜样腺癌患者预后的关系.方法 收集浙江省肿瘤医院2001年1月-2008年12月间收治的原发性子宫内膜样腺癌患者256例,其中合并MS者96例,未合并MS者160例.随访截止时间为2013年12月,随访5～12年,回顾性分析是否合并MS的子宫内膜样腺癌患者的生存情况,并对MS及其组分（MS组分包括腰围、甘油三酯、高密度脂蛋白、血压、血糖）对子宫内膜样腺癌患者预后的影响进行分析.结果 （1）随访期内,256例子宫内膜样腺癌患者中,存活194例,其中合并MS者64例,占33.0％（64/194）;死亡62例,其中合并MS者32例,占51.6％（32/62）,两者比较,差异有统计学意义（χ^2=6.953,P=0.008）.256例子宫内膜样腺癌患者的5年累积总生存率为75.8％,生存时间为（78.0±3.4）个月.其中,96例合并MS患者的5年累积总生存率为66.7％,生存时间为（67.0±2.4）个月;160例未合并MS患者的5年累积总生存率为81.3％,生存时间为（85.0±4.0）个月,两者分别比较,差异均有统计学意义（P＜0.05）.（2）合并MS、体质指数≥25 kg/m2、腰围＞80 cm、血压异常、血糖异常、同时合并MS组分≥2项者是影响子宫内膜样腺癌患者预后的独立因素（P＜0.05）.结论 MS及其组分是影响子宫内膜样腺癌患者预后的不良因素.Objective To study the association between metabolic syndrome （MS） and prognosis of endometrioid carcinoma.Methods A total of 256 patients with endometrioid carcinoma at,Zhejiang Cancer Hospital between January,2001 and December,2008 were chosen.The deadline for follow up was December 2008.The general conditions（including age and body mass index）,whether coupled with MS and it＇s risk factors（including waist circumference,fasting plasma glucose,triglycerides,high-densitylipoprotein,systolic and diastolic blood pressure） were analyzed.The outcome of 256 patients whether coupled with MS were analyzed using Kaplan-Meier curve.Relative risks were estimated using Cox proportional hazards regression model.Results A total of 256 cases were followed-up successfully.Sixtyfour （33.0%） cases coupled with MS among the 194 patients survived,while thirty-two （51.6%）coupled with MS from 62 cases died,there was significant difference between them （χ^2=6.953,P=0.008）.The total fiveyear survival rate was 75.8%,the survival time was （78.0±3.4） months.The rate and the survival time of patients coupled with MS [66.7%,（67.0±2.4） months] were significatly lower than those coupled with no MS [81.3%,（85.0±4.0） months;P〈0.05].The Cox proportional hazards regression results showed that coupled with MS,body mass index ≥25 kg/m^2,waist circumference〉80 cm,abnormol systolic and diastolic blood pressure,abnormal fasting plasma glucose and more than two components of definitions of MS were related to bad prognosis of endometrioid carcinoma（P〈0.05）.Conclusion Metabolic syndrome may be lead to a bad prognosis of endometrioid carcinoma.

关 键 词：癌 子宫内膜样 代谢综合征X 预后 

分 类 号：R737.33[医药卫生—肿瘤]