蛋白激酶与神经变性疾病  

Protein kinases and neurodegenerative diseases

作　　者：杨胜乾[1] 杜冠华[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国药理学与毒理学杂志》2014年第5期748-757,共10页Chinese Journal of Pharmacology and Toxicology

摘　　要：神经变性疾病是由于神经元或者髓鞘的损伤、丢失引起的神经系统疾病,其病因复杂,影响因素甚多,发病机制尚不完全明确。蛋白激酶在神经变性疾病的发生发展过程中发挥着重要的作用。然而,蛋白激酶抑制剂能有效保护神经细胞,缓解或减轻神经变性疾病的病情。本文就阿尔茨海默病、帕金森病、亨廷顿病等神经变性疾病中所涉及的蛋白激酶及其抑制剂进行综述,分析各蛋白激酶与主要神经变性疾病疾病之间的相互关系,为针对这些疾病的药物研发提供新的思路和策略,认为新型复方药物可能成为治疗神经变性疾病药物研发的方向。Neurodegenerative diseases are complex nervous system disorders as a result of myelin damage,synapses loss and/ or neuron loss. The pathogenesis of these diseases is still not completely clear. Protein kinases play an important role in both normal nerve cells and neurodegenerative disorders. lnhibitors of protein kinases can effectively regulate the physiological function of nerve cells and prevent the development and progression of the disease. This article reviews protein kinases and their inhibitors involved in Alzheimer disease,Parkinson disease,Huntington disease and other neurodegenerative diseases.

关 键 词：蛋白激酶 神经变性疾病 阿尔茨海默病 帕金森病 亨廷顿病 蛋白激酶抑制剂 

分 类 号：R741.02[医药卫生—神经病学与精神病学]