Notch信号通路对胶质瘤干细胞的调控作用研究进展  

Advance on the mechanism of Notch signaling pathway regulation on glioma stem cells

作　　者：陈声波[1] 刘子豪[1] 杜彬[1] 

机构地区：[1]暨南大学医学院病理教研室,广东广州510632

出　　处：《基础医学与临床》2014年第11期1566-1569,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(31201028);暨南大学大学生创新创业训练计划(1055912177);广东省医学科研基金(A2011328)

摘　　要：胶质瘤干细胞(GSCs)是胶质瘤放化疗耐受和复发的重要原因。而Notch信号通路对GSCs形成、维持及胶质瘤患者放化疗耐受中起关键的调控作用。因此,深入研究GSCs中Notch信号通路调控机制对开发以该通路为靶向的治疗药物具有积极意义。Glioma stem cells play a crucial role in glioma recurrence and resistance to radio-and chemotherapy.Notch signaling pathway was involved in glioma stem cells＇ forming and maintaining.Moreover,Notch activation was contributed to chemotherapy and radiotherapy of resistance in glioma.Therefore,the study on Notch signaling pathway of glioma stem cells significantly facilitating the development of targeted treatment.

关 键 词：NOTCH信号 胶质瘤干细胞 抗治疗 干细胞维持 

分 类 号：R739.41[医药卫生—肿瘤]