细胞毒T淋巴细胞相关抗原4(CTLA-4)基因多态性与牙周炎患者的关系研究  

Gene polymorphism of cytotoxic T lymphocyte associated antigen-4 in Chinese periodontitis patients

作　　者：宋卫东[1] 马丽霞[1] 王春英[1] 刘杨[1] 

机构地区：[1]兰州军区兰州总医院体检中心口腔科,甘肃兰州730050

出　　处：《西北国防医学杂志》2014年第5期443-446,共4页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:通过检测CTLA-4+49A/G,-318C/T基因型在牙周炎患者中的分布进而分析CTLA-4基因多态性与牙周炎发生、发展的相关性。方法:采用多聚酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)检测55例慢性牙周炎,48例侵袭性牙周炎以及80例健康对照者中CTLA-4+49A/G,-318C/T基因型频率,统计分析其在慢性牙周炎及侵袭性牙周炎患者中的差异性。结果:CTLA-4+49等位基因G及基因型GG在慢性牙周炎患者中的频率显著高于健康对照组,而在侵袭性牙周炎患者中无显著差异;而无论在慢性牙周炎还是侵袭性牙周炎中CTLA-4-318C/T等位基因及基因型频率均无显著差异。结论:CTLA-4基因多态性与牙周炎的发生、发展可能存在相关性,CTLA-4+49等位基因G及基因型GG是慢性牙周炎的易感因子;此外,CTLA-4-318C/T基因多态性与牙周炎的易感性无关。Objective：To explore the potential correlation between gene polymorphism of CTLA-4 and pathogenesis of periodontitis by detecting the distribution of CTLA-4＋49A/G and -318C/T in patients with periodontitis. Methods.. The genotype frequencies of CTLA-4＋49A/G and -318C/T in 55 cases of chronic periodontitis,48 cases of aggressive periodontitis and 80 healthy volunteers were evaluated by PCR -RFLP. Results：The frequencies of allele ＂G＂ and genotype ＂GG＂ at CTLA-4＋49 site were significantly higher in patients with chronic periodontitis but not in patients with aggressive periodontitis than those in healthy volunteers. But the frequencies of allele and genotype at CTLA-4-318C/T site in patients with chronic or aggressive periodontitis were not different with those in healthy volunteers. Conclusion： Gene polymorphism of CTLA-4 may be implicated in the pathogenesis of periodontitis. The allele ＂G＂ and the genotype ＂GG＂ are the susceptible factors to chronic periodontitis. Besides, gene polymorphism of CTLA- 4-318C/T is not related with the susceptibility to periodontitis.

关 键 词：牙周炎 CTLA-4 基因多态性 

分 类 号：R781.4[医药卫生—口腔医学]