奈达铂联合重组人白细胞介素-2腹腔灌注治疗恶性腹腔积液的疗效  

Intraperitoneal Infusion of Nedaplatin Combined with Recombinant Human Interleukin-2 for Malignant Ascites

作　　者：王薇[1] 

机构地区：[1]中国人民武装警察部队学院医院外科,河北廊坊065000

出　　处：《实用临床医学（江西）》2014年第8期12-14,共3页Practical Clinical Medicine

摘　　要：目的观察奈达铂联合重组人白细胞介素-2腹腔灌注姑息治疗恶性腹腔积液的临床疗效及不良反应。方法对34例晚期肿瘤伴恶性腹腔积液患者采用奈达铂60 mg·m-2+生理盐水50 mL+地塞米松5 mL,重组人白细胞介素-2 300万U+生理盐水30 mL腹腔灌注治疗,1次·d-1,连续腹腔灌注1周为1个周期,治疗2、4周期后行B超检查,进行疗效评价。结果 2周期腹腔灌注后完全缓解(CR)4例(11.8%),部分缓解(PR)13例(38.2%),稳定(SD)9例(26.4%),进展(PD)8例(23.5%),2周期治疗有效率(RR)为50.0%,疾病控制率(DCR)为66.4%;4周期腹腔灌注后CR 6例(17.6%),PR 15例(44.1%),SD 3例(8.8%),PD 10例(29.4%),4周期治疗RR为61.7%,DCR为70.5%。腹腔灌注最常见不良反应是恶心、呕吐、肝功能受损、骨髓抑制以及流感样症状,未见Ⅳ度不良反应出现。结论奈达铂联合重组人白细胞介素-2腹腔灌注治疗恶性腹腔积液能在局部达到很好的控制效果,且价格低廉,患者耐受性好,可用于晚期肿瘤患者恶性腹腔积液的姑息治疗。Objective To investigate the efficacy and adverse reactions of intraperitoneal infusion of nedaplatin combined with recombinant human interleukin-2 in the palliative treatment of malignant ascites. Methods Thirty-four patients with advanced tumors complicated by malignant ascites were treated with intraperitoneal infusion of 60 mg·m^-2 nedaplatin plus 50 mL normal saline plus 5 mL dexamethasone and 3 million IU recombinant human interleukin-2 plus 30 mL normal saline once daily for 1 week as a treatment cycle. After 2 and 4 cycles of treatment, B-mode ultrasonography was performed and clinical efficacy was evaluated in all patients. Results After 2 cycles of intraperitoneal infusion, complete remission（CR） was achieved in d patients（ll.8%）, partial remission（PR） in 13 （38.2%）, stable disease（SD） in 9（26.4%）, and progressive disease（PD） in 8 （23.5%）.The 2-week response rate（RR） and disease control rate（DCR） were 50% and 66.4%, respectively. After 4 cycles of intraperitoneal infusion, CR was achieved in 6 patients （17.6%）, PR in 15 （44.1%）, SD in 3 （8.8%）, and PD in 10（29.4%）.The 4-week RR and DCR were 61.7% and 70.5%, respectively. The common adverse reactions included nausea, vomiting, liver damage, myelosuppression, and flu-like symptoms. No patients had IV adverse reactions. Conclusion Intraperitoneal infusion of recombinant human interleukin-2 is effective, inexpensive and well tolerated of malianant ascites in oatients with advanced tumors. nedaplatin combined with for the palliative treatment

关 键 词：奈达铂 重组人白细胞介素-2 腹腔灌注 恶性腹腔积液 晚期肿瘤 

分 类 号：R730.6[医药卫生—肿瘤]