正交试验法优选营心宁胶囊挥发油β-环糊精包合工艺  

Optimization of β-Cyclodextrin Inclusion Process for Volatile Oil in Yingxinning Capsules by Orthogonal Test

作　　者：王薇[1,2] 周妍[1] 范彦博[1,2] 严启伟[1] 周才新[1,2] 

机构地区：[1]武汉市中医医院,武汉430014 [2]武汉市中医药研究所国家中管局中药制剂三级实验室

出　　处：《中国药师》2014年第10期1680-1681,共2页China Pharmacist

摘　　要：目的:优选营心宁胶囊中β-环糊精(β-CD)包合挥发油的最佳工艺。方法:采用L9(34)正交试验法,以包合物中含油量为考察指标,以挥发油:β-CD、包合温度、包合时间及搅拌速度为考察因素优选工艺。结果:优选的包合工艺为:挥发油:β-CD为1:9,包合温度40℃,包合时间为30 min,搅拌速度800 r·min-1。结论:优选的工艺简便可行,稳定性好,挥发油提取量最高。Objective：To optimize β-cyclodextrin （β-CD） inclusion process for volatile oil in Yingxinning capsules. Methods：The content of volatile oil in theβ-CD inclusion compound as the evaluation index, the ratio of volatile oil toβ-CD, inclusion tempera-ture, inclusion time and stirring speed as the influencing factors, the inclusion process was studied using L9（34）orthogonal design. Re-sults：The best preparation conditions were as follows：the ratio of volatile oil toβ-CD was 1∶ 9, the inclusion temperature was 40℃, the inclusion time was 30min and the stirring speed was 800 r·min^-1 . Conclusion： The preparation technology is simple, feasible and stable with high inclusion rate of volatile oil.

关 键 词：营心宁胶囊 挥发油 Β-环糊精 包合物 正交试验法 

分 类 号：R283.6[医药卫生—中药学]