视网膜血管内皮细胞在自身免疫性后葡萄膜炎中的作用  

Role of retinal vascular endothelial cell in autoimmune posterior uveitis

作　　者：毕泗松 崔彦[2] 毕宏生[2] 

机构地区：[1]山东中医药大学,山东省济南市250002 [2]山东中医药大学附属眼科医院,山东中医药大学眼科研究所,山东省济南市250002

出　　处：《眼科新进展》2014年第11期1091-1093,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81100658、81373826、81072961);山东省自然科学基金资助(编号:2R2010HM048)~~

摘　　要：视网膜血管内皮细胞(retinal vascular endothelial cell,RVEC)组成的微血管起到了对视网膜提供营养,排出代谢产物和保护视力的重要作用。另外,RVEC能保证血管内的物质循环,维持视网膜微血管的正常形态并且能阻止潜在的病原体侵入。RVEC还参与组成血-视网膜屏障,并排出微血管循环中的分子毒素、微生物和促炎因子。然而,正是因为具有这些特点,它也可能参与视网膜疾病的发生,例如新生血管、血管出血和炎症细胞。RVEC也可以参与后葡萄膜炎中缺血性病变的形成。本文就RVEC在自身免疫性后葡萄膜炎中的作用作一综述。The microvessels composed by retinal vascular endothelial cells（ RVEC） supply and drain the neural retina,and are consistent with nutritional requirements and protection of a tissue critical to vision. On the one hand,RVEC must ensure nutrients to the metabolically active retina,and allow access to circulating cells that maintain the vasculature or survey the retina for the presence of potential pathogens. On the other hand,RVEC contributes to the blood-retinal barrier that protects the retina by excluding circulating molecular toxins,microorganisms,and proinflammatory leukocytes. However,features required to fulfill these functions may also predispose to disease processes,such as retinal vascular leakage and neovascularization. Thus,RVEC is a key participant in retinal ischemic vasculopathies in posterior uveitis. This article reviews the role of RVEC in autoimmune posterior uveitis.

关 键 词：视网膜血管内皮细胞 自身免疫性后葡萄膜炎 黏附分子 趋化因子 炎症反应 

分 类 号：R774[医药卫生—眼科]