乳腺癌合并高血压患者的临床特征及化疗影响因素  

Clinical features of breast cancer patients with hypertension and influencing factors of chemotherapy

作　　者：刘君君[1] 陈小松[1] 毛艳[1] 高卫奇[1] 沈坤炜[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院乳腺疾病诊治中心,上海200025

出　　处：《上海交通大学学报（医学版）》2014年第10期1476-1480,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81172520)~~

摘　　要：目的探讨乳腺癌合并高血压患者的临床病理特征、治疗及接受化疗的影响因素。方法回顾性分析186例乳腺癌合并高血压患者(观察组)和671例单纯乳腺癌患者(对照组)的临床资料和治疗情况。结果观察组患者与对照组患者比较,平均年龄较大,绝经后患者比例较高,接受化疗的患者比例较低,差异均有统计学意义(P<0.001)。2组患者肿瘤大小、病理分级、淋巴结状态以及激素受体、HER-2、ki67表达等临床指标比较,差异均无统计学意义(P>0.05)。Logistic回归分析结果显示:年龄、是否合并高血压、淋巴结状态以及激素受体、HER-2、ki67表达是决定患者是否接受化疗的影响因素(P<0.05)。结论乳腺癌合并高血压患者的临床病理特征与单纯乳腺癌患者无明显差异,接受化疗比例较低。合并高血压是影响乳腺癌患者是否接受化疗的重要因素。Objective To investigate the clinical pathological features of breast cancer patients with hypertension and influencing factors of the treatment and chemotherapy. Methods The clinical data and treatments of 186 breast cancer patients with hypertension（ the observation group） and 671 breast cancer patients without complications（ the control group） were retrospectively analyzed. Results Compared to the control group, the average age of the observation group was older; the rate of postmenopausal patients was higher; and the rate of undergoing chemotherapy was lower.The differences were statistically significant（ P 〈0. 001）.The differences of tumor size, pathological grade, lymph node status, hormone receptor, and expressions of HER2 and ki67 were not statistically significant（ P〉 0. 05）. Results of the Logistic regression analysis showed that the age,combined with hypertension, lymph node status, hormone receptor, and expressions of HER2 and ki67 were influencing factors of chemotherapy（ P 〈0. 05）. Conclusion The differences of clinical pathological features of breast cancer patients with hypertension and breast cancer patients without complications are not significant.The rate of undergoing chemotherapy of breast cancer patients with hypertension is lower than that of breast cancer patients without complications.Combined with hypertension is an important influencing factor for the chemotherapy of breast cancer patients.

关 键 词：高血压 乳腺癌 化疗 

分 类 号：R737.9[医药卫生—肿瘤]