甲状腺乳头状癌的超声造影表现及其病理基础  

Contrast-enhanced Ultrasonography Findings for Papillary Thyroid Carcinoma and Its Pathological Bases

作　　者：马步云[1] 金亚[1] Parajuly Shyam Sundar 赵海娜[1] 姜勇[2] 周洁宏[1] 

机构地区：[1]四川大学华西医院超声科,成都610041 [2]四川大学华西医院病理科,成都610041

出　　处：《四川大学学报（医学版）》2014年第6期997-1000,共4页Journal of Sichuan University(Medical Sciences)

基　　金：成都市科技局项目(No.ZH13029)资助

摘　　要：目的探讨甲状腺乳头状癌的超声造影表现及其病理基础。方法对72例甲状腺结节患者进行常规超声和彩色多普勒超声检查,将TI-RADS≥3级的86个结节进行超声造影(CEUS)检查,经过手术和病理证实均为甲状腺乳头状癌;分析结节及甲状腺的CEUS表现,术后结节及甲状腺的病理进行CD34免疫组织化学染色。结果 86个结节的Adler血流分级分别为:0级26个,Ⅰ级34个,Ⅱ级23个,Ⅲ级3个。CEUS增强强度为低增强71个,等增强12个,高增强3个。结节与周围组织的平均强度、峰值强度、曲线下面积和CD34计数的差异有统计学意义(P<0.001),均明显低于周围组织。结论甲状腺乳头状癌的CEUS增强强度以低增强为主,其病理基础是与周围组织的微血管密度差异。Objective To investigate the findings of contrast-enhanced ultrasound for papillary thyroid carcinoma and its pathological bases.Methods Seventy two（72）patients with thyroid nodules underwent routine conventional ultrasound and color Doppler examination,and 86 nodules with TI-RADS≥3 were examined by contrast-enhanced ultrasound（CEUS）.Histopathological examination was kept as standard reference and the findings of CEUS were analyzed.Pathological studies of all nodules were made after post-operative CD34 immunohistochemistry staining examination.Results Of the total 86 nodules,Adler CDFI classification grades were：grade 0-26,grade Ⅰ-34,grade Ⅱ-23 and grade Ⅲ-3nodules respectively.Enhancement pattern on CEUS showed that there was low enhancement on 71 nodules,iso-enhancement on 12 and high enhancement on 3nodules.The differences of echo mean intensity,the peak intensity,area under the curve for enhancement intensity and CD34 count between the nodules and surrounding tissue were statistical significant（P〈0.001）.Conclusion Low enhancement pattern on CEUS is the most common finding for papillary thyroid carcinoma,which is related to the difference of microvessel density between the nodules and surrounding tissues in papillary thyroid carcinoma.

关 键 词：甲状腺乳头状癌 超声造影 微血管密度 

分 类 号：R736.1[医药卫生—肿瘤]