miRNA-146a rs2910164基因多态性与肝癌易感性的Meta分析  

Meta-analysis of the association between miRNA-146a rs2910164 polymorphism and susceptibility to hepatocellular carcinoma

作　　者：谢文群[1] 谭诗云[1] 王晓凡[1] 

机构地区：[1]武汉大学人民医院消化内科,湖北武汉430060

出　　处：《中华肿瘤防治杂志》2014年第19期1562-1566,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：湖北省科技厅重点项目(20BCFA076)

摘　　要：目的系统评价miRNA-146ars2910164基因多态性与肝癌易感性之间的相关性。方法全面检索PubMed、Excerpta Medica Database（Embase）、中国生物医学文献数据库（Chinese Biomedical Literature Database,CBM）、the Cochrane Library、维普、谷歌学术和万方数据库,文献检索起止时间均为从建库至2013-11。搜集研究miRNA-146a rs2910164基因多态性与肝癌相关性的文献。对miRNA-146ars2910164G/C各基因型比较模型,包括G与C、GG与CC、GG与GC、GC与CC、GG＋GC与CC以及GG与GC＋CC,在病例组和对照组的分布情况进行定量综合分析。结果共纳入9篇文献,共有2 951例肝癌及3 217名健康对照。miRNA-146ars2910164基因多态性与肝癌易感性之间具有相关性,GG与CC比较的OR=1.21,95%CI为1.04～1.42,P=0.02;GC与CC比较的OR=1.15,95%CI为1.02～1.29,P=0.02;GG＋GC与CC比较的OR=1.16,95%CI为1.04～1.29,P=0.009。亚组分析结果发现,在亚洲人群中也有相似的结论,GC与CC比较的OR=1.15,95%CI为1.02～1.29,P=0.02;GG＋GC与CC比较的OR=1.16,95%CI为1.04～1.30,P=0.009。结论 miRNA-146ars2910164基因多态性与肝癌易感性之间具有相关性,并且miRNA-146a rs2910164基因多态性的CC基因型可能是肝癌的保护因素。OBJECTIVE To evaluate the association between between miRNA-146a rs2910164 polymorphism and susceptibility to hepatocellular carcinoma by Meta-analysis.METHODS An electronic search for relevant articles was conducted in PubMed,Excerpta Medica Database（Embase）,Chinese Biomedical Literature Database（CBM）,the Cochrane Library,Weipu,Google academic and Wanfang database.We based our time on literature retrieval from inception to November,2013.We collected all the publications about the association between miR-146a rs2910164 polymorphism and risk of hepatocellular carcinoma.Then,we analyzed the difference of miRNA-146a rs2910164genotype（Gvs C,GGvs CC,GG vs GC,GC vs CC,GG＋GC vs CC,GGvs GC＋CC）between cases and controls through Meta-analysis.RESULTS Ultimately,a total of 9studies involving 6 168 subjects were found to be eligible for our Meta-analysis.In our Meta-analysis,significantly increased cancer risks were found in three genetic comparisons in the overall analysis（GGvs CC：OR=1.21,95%CI：1.04-1.42,P=0.02;GC vs CC：OR=1.15,95%CI：1.02-1.29,P=0.02;GG＋GC vs CC：OR=1.16,95%CI：1.04-1.29,P=0.009）.In the subgroup analysis by ethnicity,similar results were found among Asians in two genetic models（GC vs CC：OR=1.15,95%CI=1.02-1.29,P=0.02;GG＋GC vs CC：OR=1.16,95%CI：1.04-1.30,P=0.009）.CONCLUSIONS Our Meta-analysis suggested that miR-146a rs2910164 polymorphism was more likely to be associated with hepatocellular carcinoma risk.Besides,the CC genotype of rs2910164 in miR-146 agene might be associated with protection from hepatocellular carcinoma.

关 键 词：肝癌 MIRNA 基因多态性 META分析 

分 类 号：R735.7[医药卫生—肿瘤]