Individual Patient Data Meta-Analysis Is Needed in Chinese Medical Research  

作　　者：闫世艳 何丽云 刘保延 

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences [2]China Academy of Chinese Medical Sciences

出　　处：《Chinese Journal of Integrative Medicine》2014年第11期805-811,共7页中国结合医学杂志（英文版）

基　　金：Supported by the Fundamental Research Funds for the CentralPublic Welfare Research Institutes of China(No.ZZ070818 andZ0259);National Natural Science Foundation of China(No.81072920 and 81303149)

摘　　要：Publication biases and collection limitations are the main disadvantages of a traditional meta-analysis based on aggregate patient data（APD）from published articles.Individual patient data（IPD）meta-analysis,as the gold standard of systematic review,is a possible alternative in this context.However,the publications relative to IPD meta-analyses are still rare compared with the traditional ones,especially in the research oriented to Chinese medicine（CM）.In this article,the strengths and detailed functioning of IPD meta-analysis are described.Furthermore,the need for IPD meta-analysis to assess the treatments based on CM was also discussed.Compared with the traditional APD meta-analysis,the IPD meta-analysis might give a more accurate and unbiased assessment and is worth to be recommended to CM researchers.Publication biases and collection limitations are the main disadvantages of a traditional meta-analysis based on aggregate patient data（APD）from published articles.Individual patient data（IPD）meta-analysis,as the gold standard of systematic review,is a possible alternative in this context.However,the publications relative to IPD meta-analyses are still rare compared with the traditional ones,especially in the research oriented to Chinese medicine（CM）.In this article,the strengths and detailed functioning of IPD meta-analysis are described.Furthermore,the need for IPD meta-analysis to assess the treatments based on CM was also discussed.Compared with the traditional APD meta-analysis,the IPD meta-analysis might give a more accurate and unbiased assessment and is worth to be recommended to CM researchers.

关 键 词：meta-analysis individual patient data systematic review randomized clinical trial Chinese medicine 

分 类 号：R-33[医药卫生]