间变性大细胞淋巴瘤的临床细胞病理学分析  

Clinical analyses of Anaplastic large cell lymphoma through cytopathology

作　　者：康劲松[1] 雷清华[2] 刘利敏[1] 李钫[1] 赵雅桐[1] 

机构地区：[1]华中科技大学同济医学院同济医院外科细胞室,武汉430030 [2]华中科技大学同济医学院基础医学院解剖学系

出　　处：《临床血液学杂志（输血与检验）》2014年第5期860-861,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的：探讨间变性大细胞淋巴瘤（anaplastic large cell lymphoma，ALCL）的临床细胞病理学特点、免疫表型及鉴别诊断，提高对ALCL的认识。方法：分析经组织病理学证实的13例ALCL的临床表现、细胞病理学形态及免疫表型，并结合相关文献进行讨论。结果：13例ALCL患者中，ALK阳性11例，ALK阴性2例；全部表达CD30，部分表达EMA、CD3、CD45RO、CD43，不表达CD3、CD56、CD20、CD79a、PCK、CDll7；Ki67LI60％～100％。结论：ALCL是一种少见的非霍奇金淋巴瘤，依据其细胞病理学形态特征，细胞病理学可以做出正确的诊断，但应注意与霍奇金淋巴瘤、弥漫大B细胞淋巴瘤、恶性黑色素瘤、未分化癌等进行鉴别；当鉴别诊断有困难时，应行活检及免疫组织化学染色以确诊。Objective：To explore the clinical cytopatbological features, immunophenotype and differential diag- nosis of anaplastic large cell lymphoma （ALCL） and improve the understanding of ALCL. Method：Thirteen cases of ALCL were diagnosed with histopathology. Their clinical manifestation, cytopathological mophology and immu- nophenotype were analyzed, and related literatures were involved and discussed. Result：In 13 cases of ALCLs, 11 cases were ALK-positive and 2 cases ALK-negative; all cases expressed CD30, part of them expressed EMA, CD3, CD45RO, and CD43; none o{ them expressed CD3, CD56, CD20, CD79a, PCK, CD117; Ki67LI 600/4- 100%. Conclusion：ALCL is a kind of non Hodgkin＇s lymphoma which is rarely seen and should be differentiated from Hodgkin lymphoma, diffuse large B cell lymphoma, malignant melanoma and undifferentiated carcinoma. Correct cytopathological diagnosis can be made on its morphological characteristics. When the differential diagno- sis is difficult, some assistive technology, such as biopsy and immunohistochemical staining, should be applied.

关 键 词：间变性大细胞淋巴瘤 临床 细胞病理学 

分 类 号：R733[医药卫生—肿瘤]