肺癌患者血栓前状态分子标志物的变化  

Changes of pre-thrombotic state indexes in patients with lung cancer

作　　者：沈立[1] 朱成华[1] 杜强[1] 蔡健康[1] 

机构地区：[1]南京医科大学第二附属医院呼吸科,江苏南京210011

出　　处：《临床肺科杂志》2014年第12期2239-2242,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究肺癌患者血栓前状态(prethmmbotic state PTS)分子标志物变化并探讨其意义。方法采用酶联免疫吸附双抗体夹心法检测82例肺癌患者和50名正常人凝血、抗凝纤溶系统实验室指标,包括血小板α颗粒膜蛋白-140(GMP-140)、凝血酶原片段1+2(F1+2),凝血酶-抗凝血酶复合物(TAT),D-二聚体(D-dimer)。结果肺癌患者体内GMP-140、F1+2、TAT、D-dimer的水平较正常人显著升高(P<0.05),上述指标在晚期肺癌组和PS评分>2的患者中明显升高(P<0.05)。结论肺癌患者出现血小板活化、凝血功能增强、纤溶功能减退,存在明显的血栓前状态。Objective To study the changes and significance of pre-thrombotic state indexes in patients with lung cancer. Methods The plasma levels of platelet α-granule membrane protein-140 （ GMP-140 ） , thrombin-an-tithrombin complex （TAT）, fibrinopeptide 1＋2（F1＋2） and D-dimer （D-D） were measured by ELISA technique in 82 patients with lung cancer and in 50 normal controls. Results The levels of GMP-140, TAT, PF1＋2 and D-Di-mer were significantly higher in patients with lung cancer than in the controls, and they were also obviously higher in those lung cancer patients who were at advanced stage or PS score 〉2 （P〈0. 05）. Conclusion The platelet is ac-tivated,the thrombin activity increases,and the fibrinolytic function declines in patients with lung cancer. There is an obvious pre-thrombotic state in patients with lung cancer.

关 键 词：肺癌 血栓前状态 血小板Α颗粒膜蛋白-140 凝血酶原片段1+2 凝血酶-抗凝血酶复合物 D-二聚体 

分 类 号：R734.2[医药卫生—肿瘤]