血浆D-二聚体检测在诊断肝硬化腹腔积液患者自发性细菌性腹膜炎中的应用  

The application of plasma D-dimer in the diagnosis of spontaneous peritonitis in cirrhotic patients with ascites

作　　者：徐卫益[1] 陈保德[1] 许青[1] 

机构地区：[1]浙江大学医学院附属第一医院检验科,浙江杭州310003

出　　处：《国际检验医学杂志》2014年第21期2883-2884,共2页International Journal of Laboratory Medicine

基　　金：浙江省教育厅基金资助项目(Y201226248)

摘　　要：目的了解血浆D-二聚体(D-D)浓度在肝硬化腹腔积液患者自发性细菌性腹膜炎(SBP)诊断中的应用价值。方法留取肝硬化腹腔积液患者137例,分为SBP组和非自发性细菌性腹膜炎(NSBP)组,另选取慢性肝病患者30例(慢性肝病组)及30例健康者(健康对照组),分别测定各组D-D和C反应蛋白(CRP)浓度。结果 SBP组、NSBP组、慢性肝病组、健康对照组D-D浓度分别为(7.82±5.68)、(5.55±4.55)、(0.45±0.26)、(0.06±0.04)mg/L;血清CRP分别为(30.0±29.6)、(16.4±20.5)、(5.3±1.8)、(2.1±0.9)mg/L。SBP组和NSBP组D-D、CRP浓度均明显高于慢性肝病组和健康对照组(P<0.01)。SBP组D-D、CRP浓度高于NSBP组,差异也有统计学意义(P<0.05)。ROC曲线分析显示,D-D诊断SBP的曲线下面积、灵敏度、特异度分别为0.650、0.604、0.709;CRP分别为0.705、0.792、0.582。结论检测D-D有助于肝硬化腹腔积液患者SBP的早期诊断。Objective To investigate the application value of plasma D-dimer（D-D）in the diagnosis of spontaneous bacterial peritonitis（SBP）in patients with liver cirrhosis.Methods 137 cases of cirrhotic patients with ascites were selected and divided into SBP group and non SBP（NSBP）group.30 cases of patients with chronic liver disease and 30 healthy individuals were selected as chronic liver disease group and normal control group,respectively.The levels of D-D and C-reactive protein（CRP）were measured in specimens from all the groups.Results The D-D levels of SBP group,NSBP group,chronic liver disease group and normal control group were（7.82±5.68）,（5.55±4.55）,（0.45±0.26）and（0.06±0.04）mg/L,respectively.And the serum CRP levels were（30.0±29.6）,（16.4±20.5）,（5.3±1.8）and（2.1±0.9）mg/L,respectively.The levels of D-D and CRP were both higher in SBP group and NSBP group than in chronic liver disease group and normal control group（P〈0.01）.The D-D and CRP levels of SBP group were both significantly higher than those of NSBP group（P〈0.05）.The ROC curve showed that the AUC,sensitivity and specificity of D-D were 0.650,0.604 and 0.709,respectively,and those of CRP were 0.705,0.792 and 0.582,respectively.Conclusion Plasma D-D detection was beneficial to the early diagnosis of SBP in cirrhotic patients with ascites.

关 键 词：D-二聚体 C反应蛋白 肝硬化 腹膜炎 

分 类 号：R575.2[医药卫生—消化系统]