青蒿素及其衍生物在抗血液系统肿瘤中的研究进展  

Progress on Anti-Tumor in Hematology System of Artemisinin and Its Derivative

作　　者：吴逢选 叶宝东[2] 周郁鸿[2] 

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江中医药大学附属第一医院,浙江杭州310006

出　　处：《中华中医药学刊》2014年第11期2623-2625,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医临床研究基地业务建设科研专项课题(JDZX2012176)

摘　　要：青蒿素及其衍生物在体内外具有较强的抗肿瘤活性,其机制主要与诱导肿瘤细胞凋亡、抑制肿瘤血管生成、使肿瘤细胞内钙离子升高等有关。目前,该类药物在血液系统中的抗肿瘤作用已得到研究者认可,但作用机制尚未得到统一。现对其抗肿瘤机制研究进展及在血液病中的应用做一综述以供临床参考。Artemisinin and its derivative have a strong antitumor activity in vitro and in vivo. The main mechanisms are related, inducing tumor cell apoptosis, inhibiting angiogenensis of tumor, increasing intracellular calcium ion of tumor cells, and so on. Currently, the anti - tumor effect of these drugs in the hematology system has been approved by research- ers,although the mechanisms have not fully uniformed. This review summarizes the progress on the anti - tumor mechanisms of artemisinin and its derivative in hematology system and provides some references for clinical applications.

关 键 词：青蒿素 双氢青蒿素 青蒿琥酯 血液 肿瘤 

分 类 号：R781.62[医药卫生—口腔医学]