痴呆的中医证型和方药规律分析  

Analysis on the Rules of TCM Patterns /Syndromes and Herbal Formulas in Treatment of Dementia

作　　者：司富春[1] 陈瑞[1,2] 

机构地区：[1]河南中医学院中医药分子生物实验室,郑州河南450046 [2]河南中医学院

出　　处：《世界中西医结合杂志》2014年第10期1119-1122,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：国家回国留学人员基金优秀项目[No.(2007)170];河南省国际科技合作项目(No.104300510019);河南省科技创新团队项目(No.2010-29);郑州市科技创新团队项目(No.10CXTD145);河南中医学院科技创新团队(No.2010XCXT05);河南省中医学博士后科技创新团队(2012)

摘　　要：目的对1979年1月-2014年3月中国期刊全文数据库（CNKI）收录的中医治疗痴呆文献进行整理分析,寻求中医辨证论治本病的规律。方法通过使用SPSS18.0软件,对文献中的证型、方剂和药物进行统计归类,总结各药物、证型出现频次和所占比例,以及对药物和症状的聚类分析。结果通过整理分析得出35个痴呆证型,其中肝肾阴虚、痰蒙清窍、髓海不足、瘀血内阻、气滞血瘀、痰瘀互结、脾肾阳虚等为中医常见证型;共得四类症状聚类证型,分别是肝肾阴虚、髓海空虚证,气滞血瘀、肾精不足证,痰瘀互结证,脾肾阳虚证;证候要素分析,瘀血、痰浊、气滞、火旺、热盛、湿阻、肝郁为常见实性病机,气、血、阴、阳亏虚及精亏、髓亏是常见虚性病机;病位分析主要在于肾、肝、心三脏;共得方剂3558首,其中自拟方840首,成方2718首,二者皆以补益剂、理血剂、祛痰剂、清热剂为主;中药278味,分为42类,进一步归为21大类,补虚、活血、清热为常用药;常用药物进行聚类分析,得出四个聚类方,分别适用于瘀血内阻型,痰瘀互结、痰蒙清窍、髓海不足型,脾肾阳虚型,气滞血瘀、肾精亏虚型痴呆。结论痴呆的中医辨证分型和方药分析的结果,为目前本病的临床诊断、治疗和研究提供有用的参考。Objective To collect and analyze the literatures on dementia treated with TCM in CNKI from January 1979 to March 2014 so as to search the rules on pattern/syndrome differentiation and treatment of the disease in TCM. Methods SPSS18.0 software was used to classify statistically the patterns/syndromes ,formulas and medicines in the literatures. The frequency of medicines and patterns/syndromes as well as the proportion were summarized. The clustering analysis was done on medicines and symptoms. Results It was found that there were 35 patterns/syndromes of dementia. Of them, liver and kidney yin deficiency, phlegm misting the orifice, marrow sea insufficiency, internal blockage of blood stasis, qi and blood stagna- tion,interaction of phlegm and stasis and spleen and kidney yang deficiency were the common patterns/syndromes of TCM. There were four categories of clustering patterns/syndromes, named liver and kidney yin defi- ciency, marrow sea emptiness ; qi and blood stagnation, kidney essence insufficiency ; interaction of phlegm and stasis, and spleen and kidney yang deficiency. Regarding syndrome elements analysis, blood stasis, phlegm, qi stagnation, hyperactive fire, pathogenic heat, pathogenic damp and liver stagnation were the common pathogenesis of excess type ; deficiency of qi, blood, yin and yang, as well as essence deficiency and marrow deficiency were the common pathogenesis of deficiency type. The locations of disease were kidney,liver and heart. Totally,3558 formulas were used. Of them,840 formulas were the selfprepared formulas and 2718 formulas were the ready - made formulas. The tonic prescriptions, blood regulation prescriptions, phlegm resolving prescriptions and heat relief prescriptions were the chief ones. There were 278 kinds of herbs, with 42 categories,which were further classified into 21 categories. The herbs for tonifying, activating blood circulation and clearing heat were common. The clustering analysis was done on the common herbs and four clusters were concluded, applicable for demen

关 键 词：痴呆 中医 证型分析 方药分析 

分 类 号：R749.16[医药卫生—神经病学与精神病学]