大蒜素注射液对临床常见耐药菌的抗性分析  

Analysis of the Resistance of Allicin Injection on Common Drug-resistant Bacteria

作　　者：栾耀芳[1] 张苗[1] 王冠[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医杂志》2014年第11期931-932,共2页Shandong Journal of Traditional Chinese Medicine

摘　　要：目的 :观察大蒜素注射液对临床常见耐药菌的抑制杀菌效果。方法 :将大蒜素注射液运用琼脂平板稀释法,对临床常见的泛耐药(或全耐药)鲍曼不动杆菌(PDR-Ab)和铜绿假单胞菌(PDR-Pa)进行最低杀菌浓度(MBC)试验。结果:20株PDR-Ab中19株MBC为2 mg/m L,1株MBC为0.125 mg/m L;15株PDR-Pa的MBC分别为2 mg/m L 4株,1 mg/m L 3株,0.5 mg/m L 4株,0.25 mg/m L 3株,0.125 mg/m L 1株。结论 :大蒜素注射液对两组实验菌有效好杀菌效果,对PDR-Pa的效果优于PDR-Ab。Objective：To observe the bacteriostatic and bactericidal effects of allicin injection on the drug-resistant bacteria. Methods：Agar dilution method was used to detect the minimum bactericidal concentration （MBC） of allicin injection to the pan-drug resistant（or full resistant） Acinetobacter baumannii （PDR-Ab） and Pseudomonas aeruginosa（PDR-Pa）. Results：In the 20 strains PDR-Ab,the MBC in 19 strains was 2 mg/mL, and in 1 strain the MBC was 0.125 mg/mL. In the 15 strains PDR-Pa,the MBC in 4 strains were 2 mg/mL, in 3 strains were 1 mg/mL,in 4 strains were 0.Smg/mL,in 3 strains were 0.25 mg/mL,in 1 strain was 0.125mg/ mL,respectively. Conclusions：Allicin injection showed good effect in 2 groups,and the effect on PDR-Pa was better than that on PDR-Ab.

关 键 词：大蒜素 耐药菌 琼脂平板稀释 泛耐药或全耐药 最低杀菌浓度 

分 类 号：R285.5[医药卫生—中药学]