生长抑素联合奥美拉唑治疗肝硬化性消化道出血的临床疗效观察  

Clinical efficacy somatostatin plus omeprazole in treatment of cirrhosis gastrointestinal bleeding

作　　者：安启娴[1] 

机构地区：[1]云南省第二人民医院消化科,云南昆明650032

出　　处：《医药论坛杂志》2014年第11期81-82,85,共3页Journal of Medical Forum

摘　　要：目的探讨生长抑素联合奥美拉唑治疗肝硬化性消化道出血的临床疗效。方法选择2011年5月至2014年5月云南省第二人民医院收治的74例肝硬化性消化道出血患者,随机分为实验组和对照组各37例,其中实验组患者给予生长抑素联合奥美拉唑治疗,对照组患者应用奥美拉唑钠治疗,比较两组患者临床疗效、不良反应发生情况、再出血率和住院时间的差异。结果实验组患者总有效率为94.59%,对照组患者为75.68%,差异有统计学意义(P<0.05);实验组患者腹痛、腹泻、心悸、头痛等不良反应发生率为21.62%,对照组患者为16.22%,差异有统计学意义(P<0.05);实验组患者再出血率和住院时间分别为10.81%和(17.29±4.64)d,较对照组患者明显下降,差异具有显著性(P<0.05)。结论肝硬化性消化道出血患者采用生长抑素联合奥美拉唑治疗可以明显提高治疗效果,缩短住院时间,降低再出血率,减轻患者痛苦。生长抑素联合奥美拉唑治疗肝硬化性消化道出血具有安全、有效、操作简便等特点,临床值得推广应用。Objective To investigate the clinical efficacy of somatostatin plus omeprazole in treatment of cirrhosis of gastrointestinal bleeding. Methods From May 2011 to May 2014 in our hospital 74 eases of gastrointestinal bleeding in patients with cirrhosis were randomly divided into experimental group and control group 37 cases, in which the experimental group were treated with somatostatin combined with omeprazole azole treatment, the application of sodium omeprazole patients in the control group, the clinical efficacy of two groups were compared, the incidence of adverse reactions, then the difference in bleeding rates and length of stay. Results The experimental group, the total effective rate 94. 59% of patients in the control group of patients was 75.68%, the difference was statistically significant （ P 〈 0.05 ） ; Experimental group were abdominal pain, diarrhea, palpitations, headaches and other adverse reaction rate was 21.62%, control group of patients was 16. 22%, the difference was statistically significant （P 〈 0.05） ; experimental group were rebleeding rate and duration of hospitalization was 10. 81% and （ 17.29 ±4. 64） d, compared with the control group were significantly decreased, and the difference was significant （P 〈 0.05）. Conclusion Patients with cirrhosis of gastrointestinal bleeding using somatostatin plus omeprazole therapy can significantly improve the therapeutic effect, shorter hospital stays, lower rebleeding rate, reduce patient suffering. Somatostatin combined omeprazole cirrhosis gastrointestinal bleeding is safe, effective, simple operation, worthy of clinical application.

关 键 词：生长抑素 奥美拉唑 肝硬化性消化道出血 

分 类 号：R573.2[医药卫生—消化系统]