血清胰蛋白酶原-2、CA 199、CA 50、CA 242在胰腺癌诊断中的应用价值  

The value of serum trypsinogen-2,CA199,CA50,CA242 in diagnosis of pancreatic cancer

作　　者：崔婷婷[1] 张莉[1] 吴琦玮[1] 陆玓[1] 曹建彪[2] 

机构地区：[1]首都医科大学石景山教学医院北京市石景山医院消化内科,北京100043 [2]解放军北京军区总医院全军肝病治疗中心,北京100700

出　　处：《中国当代医药》2014年第31期54-57,共4页China Modern Medicine

摘　　要：目的分析血清胰蛋白酶原-2、CA199、CA50、CA242在胰腺癌诊断中的应用价值。方法选取解放军北京军区总医院、石景山医院诊为胰腺癌未经治疗的患者25例,随机选取体检中心健康体检者35例为对照组。入组者均留取血清标本,采用ELISA法半定量检测血清胰蛋白酶原-2、CA199、CA50、CA242的含量。结果血清胰蛋白酶原-2、CA199、CA50、CA242诊断胰腺癌ROC曲线下面积均>0.5(P<0.05),其中胰蛋白酶原-2曲线下面积最大,其次为CA199,CA50与CA242相仿。结论 4种血清肿瘤标志物胰蛋白酶原-2、CA199、CA50、CA242对胰腺癌均有一定的诊断价值,但因各自具有局限性,均非单一理想诊断胰腺癌的肿瘤标志物。Objective To evaluate the diagnostic value of serum trypsinogen-2,CA199,CA50,CA242 in pancreatic can-cer. Methods 25 cases of patients diagnosed pancreatic cancer,but not carried out treatment in General Hospital of Chinese PLA Beijing Command and Beijing Shijingshan Hospital were collected,35 cases of healthy people were select-ed as control group,serum samples were collected from all patients,the level of serum trypsinogen-2,CA199,CA50 and CA242 was detected by ELISA. Results The area of ROC curve of serum trypsinogen-2,CA199,CA50 and CA242 ex-ceeded 0.5 （P〈0.05）,of which,the area of ROC curve of serum trypsinogen-2 was largest,then was the CA199,CA50 and CA242 were similar. Conclusion There is certain diagnostic value of serum trypsinogen-2,CA199,CA50 and CA242 in pancreatic cancer.But all of them have linmitations,is not a single ideal diagnosis of pancreatic cancer tumor markers.

关 键 词：胰腺癌 血清胰蛋白酶原-2 CA199 CA50 CA242 

分 类 号：R735.9[医药卫生—肿瘤]