薄膜分散法制备姜黄素纳米粒的研究  

Preparation of curcumin-loaded nanoparticles by film dispersion method

作　　者：典灵辉[1] 林晓[1] 于恩江[1] 罗京彪 华玉[1] 

机构地区：[1]广东医学院药学院,东莞523808

出　　处：《食品科技》2014年第11期105-109,共5页Food Science and Technology

基　　金：东莞市国际合作项目(201350815200121);东莞市医疗卫生科技计划项目(201410515200139);广东医学院青年基金项目(KY20140203)

摘　　要：为了增加姜黄素溶解度和稳定性,采用薄膜分散法制备姜黄素纳米粒;采用粒径测定仪、透射电镜、X-射线衍射(XRD)对其进行表征,采用UV法测定纳米粒的包封率和载药量,采用动态膜透析法考察载药纳米粒的体外释药特性。制备的纳米粒呈球形或类球形,平均粒径为(61.52±2.76)nm,平均包封率为(89.95±3.57)%,平均载药量(5.62±1.02)%;XRD结果表明,姜黄素以无定型状态或分子状态包载在纳米粒中;体外释放结果表明姜黄素的纳米粒具有明显缓释作用。该纳米粒制备工艺简单,其粒径、包封率、载药量可控,具有缓释作用。To prepare curcumin-loaded nanoparticles（Cur-NPs） and evaluate their characters in vitro. The Cur-NPs were prepared by film dispersion method. The Cur-NPs were characterized by dynamic light scattering, transmission electron microscopy（TEM）, X-ray diffraction（XRD）. The release curve was determined by dialysis. Entrapment efficiency and drug loading were determined by UV. The Cur-NPs observed by TEM were spherical with a mean particle size of（61.52±2.76） nm, the entrapment efficiency（EE） and drug loading of Cur-NPs were（89.95±3.57）% and（5.62±1.02）%. Release of Cur-NPs exhibited sustained release effect. X-ray diffraction determined that curcumin was in an amorphous or molecular form within the NPs. The Cur-NPs prepared had exhibited sustained release in vitro, and the particle size, encapsulation efficiency, and drug loading are controllable.

关 键 词：姜黄素 纳米粒 薄膜分散法 

分 类 号：TS202.3[轻工技术与工程—食品科学]