^(131)I治疗分化型甲状腺癌对机体影响的研究  

The study of effect of ^(131)I therapy on body for differentiated thyroid cancer

作　　者：郝珊瑚[1] 张国旭[1] 张彤[1] 王志国[1] 张海波[2] 

机构地区：[1]沈阳军区总医院核医学科,辽宁沈阳110840 [2]沈阳军区总医院放射治疗科,辽宁沈阳110840

出　　处：《现代医学》2014年第10期1145-1149,共5页Modern Medical Journal

摘　　要：目的:探讨放射性131I治疗分化型甲状腺癌时辐射对患者的影响。方法:将69例多次行131I治疗的分化型甲状腺癌患者(累积剂量18.5~74.0 GBq)纳入研究对象,收集其治疗前及治疗后4个月时血细胞情况、肝肾功能指标及唾液腺ECT显像结果,进行统计学分析。结果:(1)131I治疗后白细胞及血小板数量较治疗前明显降低(P<0.05),但仍在正常范围内;红细胞数量略增高(P>0.05),淋巴细胞数量略有减低(P>0.05);(2)131I治疗前后患者肝肾功能指标ALT、AST、BUN、SCREA、ALP无明显变化;(3)131I治疗后患者双侧腮腺分泌及排泄功能减低(P<0.05),双侧颌下腺分泌及排泄功能略下降(P>0.05)。结论:高分化甲状腺癌的131I治疗对各系统不同程度的损伤是存在的,但绝大多数损伤是轻微的,不会带来临床恶性事件。Objective： To observe the effects of ^131I therapy on body for thyroid carcinoma patients. Methods： sixty-nine patients with DTC were inclued. They underwent ^131I radiotherapy many times（ everyone＇s total dose was 18.5 - 74.0 GBq）. The results of blood cell, liver, renal and salivary gland seintigraphy examinations were compared before and 4 months after 131i therapy. Results ： （ 1 ） The number of leukocyte and thromboeyte reduced significantly （P 〈0.05 ） 4 months after ^131I therapy but the average were in the normal ranges. The number of erythrocyte were higher（P 〉0.05）. The number of lymphocyte decreased lightly （P 〉0.05）. （2） The level of ALT, AST, BUN, SCREA, ALP about liver and renal were not significant difference between before and 4 months after ^131I radiotherapy （P 〉 0.05 ）. （3） Both parotid uptake and excretion functions were impaired（ P 〈 0.05 ） and the function of submandibular gland was not effeeted after several times of therapy （ P 〉 0.05 ）. Conclusion： The adverse effects of ^131I radiotherapy on thyroid carcinoma patients are exist but the major of adverse effects are slight.There is no serious effects after ^131I therapy.

关 键 词：甲状腺癌 ^131I治疗 副作用 

分 类 号：R734.2[医药卫生—肿瘤]