影响补铁剂脂质体磷脂水解的因素分析  

Effect of factors on phosphatide hydrolysis of iron liposome supplement

作　　者：丁保淼[1] 

机构地区：[1]长江大学生命科学学院,荆州434025

出　　处：《中国食品添加剂》2014年第7期84-87,共4页China Food Additives

基　　金：湖北省教育厅科学技术研究项目(Q20131204);湖北省高等学校青年教师深入企业行动项目(XD2012143)

摘　　要：为明确贮藏期间,内外界因素对补铁剂脂质体磷脂水解的影响,以游离脂肪酸的生成量为指标研究了壁材组成、芯壁比、芯材类型、p H、温度、缓冲液类型等因素对补铁剂脂质体磷脂水解程度的影响。实验结果表明,在壁材组成(蛋黄卵磷脂∶胆固醇)8∶1(wt./wt.),芯壁比1∶10(wt./wt.),芯材为葡萄糖酸亚铁,p H7,温度4℃,缓冲液类型为醋酸缓冲液等条件下,补铁剂脂质体磷脂水解速度较慢,补铁剂脂质体稳定性最高;同时,脂质体磷脂水解程度随着贮藏时间的延长而增加。这为提高贮藏期间补铁剂脂质体的稳定性、增加其实际应用价值提供了科学依据。Effects of inner - exterior factors on phosphatide hydrolysis of iron liposome supplement were analyzed during the storage. The content of free fatty acids was used as the indicator, and the effects of inner - exterior factors （ such as wall-material composition, core- to- wall ratio, core materials, pH, temperature, buffer solutions） on phosphatide hydrolysis of iron supplement liposome were investigated by single factor analysis. The results showed that the phosphatide hydrolysis rate of liposomes was slow down under the condition of： wall - material composition 8 ： 1 （ EPC ： CHOL, wt. /wt. ）, core-to-wall ratio 1 ： 10 （wt. /wt. ）, ferrous gluconate, pH7 at4 ℃, acetic acid buffer solution. The results provide the scientific guidance for improving the stability and application of iron liposome supplement.

关 键 词：脂质体 磷脂水解 Dole法 游离脂肪酸 

分 类 号：TS202.3[轻工技术与工程—食品科学]