血清IGF-Ⅱ含量与大肠腺瘤癌变的关系探讨  

Serum IGF-Ⅱ Level and its relationship with canceration of colorectal adenoma

作　　者：蔡军[1] 李爱民[2] 

机构地区：[1]广州军区空军后勤部医院内科,广东广州510052 [2]南方医科大学南方医院消化科,广东广州510515

出　　处：《临床军医杂志》2014年第11期1132-1133,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨血清IGF-Ⅱ含量与大肠腺瘤癌变的关系。方法选择正常健康人及增生性息肉、大肠腺瘤、大肠癌患者共104例,分为4组。利用放射免疫法(RIA)检测血清中的IGF-Ⅱ含量,然后分析比较4组血清IGF-Ⅱ含量的差异。结果正常健康人和增生性息肉患者血清中IGF-Ⅱ水平差异无统计学意义(P>0.05);而大肠腺瘤和腺癌患者血清中IGF-Ⅱ水平明显高于其他组(P<0.05)。结论大肠腺瘤和腺癌患者血清中IGF-Ⅱ含量的明显增高可能与其恶性潜能相关。Objective To investigate serum insulin-like growth factor Ⅱ （IGF-Ⅱ） level and its relationship with canceration of colorectal adenoma. Methods The content of serum IGF- Ⅱ A was detected among 104 subjects （ divided into 4 groups） with normal colonic mucosa, hyperplastic polyp, colorectal adenoma and colorectal cancer by radioimmunoassay （RIA）. Results Serum IGF-Ⅱ level was of no significant difference between the subjects with normal colonic mucosa and those with hyperplastic polyp （ P 〉 0.05）, and it was significantly higher in the subjects with either colorectal adenoma or colorectal cancer than in the other two groups （P 〈 0.05 ）. Conclusion The increase in serum IGF-Ⅱ promotes colorectal mucosa to proliferate, which may contribute to the formation and succession of human colorectal adenoma and colorectal cancer.

关 键 词：胰岛素样生长因子Ⅱ 大肠肿瘤 腺瘤 放射免疫法(RIA) 

分 类 号：R735.34[医药卫生—肿瘤]