垂体腺瘤激素水平与手术疗效相关性研究  

Correlation study of hormonal levels and surgical efficacy of pituitary adenoma

作　　者：毛天明[1] 周开宇[1] 

机构地区：[1]浙江省台州市立医院神经外科,浙江台州318000

出　　处：《中国现代医生》2014年第33期24-26,30,共4页China Modern Doctor

基　　金：浙江省医药卫生科学研究基金计划(2009A226)

摘　　要：目的探讨垂体腺瘤激素水平与手术疗效相关性。方法分析2002年8月~2014年2月于我院就诊的419例垂体腺瘤患者的临床资料,分别测定术前、术后催乳素和生长激素水平,评估两种激素水平与手术疗效的关系。结果术前血清PRL水平与垂体泌乳腺瘤术后疗效显著相关（P〈0.01）,随着术前血清催乳素水平的增高,患者术后疗效更差;而术前血清生长激素水平与垂体生长激素腺瘤术后疗效无相关性（P〉0.05）;术后无残留的垂体腺瘤患者术后血清催乳素和生长激素较术前显著降低（P〈0.05）,而术后有残留的腺瘤患者血清激素水平变化不显著（P〉0.05）,经方差分析,垂体泌乳腺瘤和生长激素腺瘤的两组患者组间、不同时点以及组间与不同时点的交互作用差异均有统计学意义（P〈0.05）。结论术前血清PRL水平可作为判断患者术后疗效的指标,临床上手术切除肿瘤时需尽量避免瘤体残留。Objective To investigate the correlation between the hormone levels and the surgical efficacy of pituitary adenoma. Methods Clinical data of 419 patients with pituitary adenoma treated in our hospital from August 2002 to February 2014 were analyzed and the preoperative and postoperative prolactin（PRL） and growth hormone levels were detected respectively. The correlation between the levels of two kinds of hormones and the surgical efficacy was evaluated. Results The preoperative serum PRL level and the postoperative efficacy of pituitary prolactin adenoma surgery was significantly related（P〈0.01）; As the preoperative serum PRL increased, the postoperative efficacy worsened. However, the serum growth hormone level and the postoperative efficacy of pituitary growth hormone adenoma surgery was not related（P〉0.05）. The postoperative serum PRL and growth hormone levels reduced significantly in the patients without postoperative residual（P〈0.05）, but the serum hormone levels did not change significantly in the patients with postoperative residual（P〉0.05）. Variance analysis showed that the pituitary prolactin adenoma group and the growth hormone adenoma group were statistically different between groups, at different time points and regarding to the interaction effect of groups and time points（P〈0.05）. Conclusion Preoperative serum PRL levels can serve as the indicators of determining postoperative efficacy and clinical tumor excision should avoid tumor residual.

关 键 词：垂体腺瘤 催乳素 生长激素 激素水平 

分 类 号：R736.4[医药卫生—肿瘤]